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Tbio
BIN3
Bridging integrator 3

Protein Summary
Description
Involved in cytokinesis and septation where it has a role in the localization of F-actin. The product of this gene is a member of the BAR domain protein family. The encoded protein is comprised solely of a BAR domain which is predicted to form coiled-coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of other processes. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276416
  • ENSP00000276416
  • ENSG00000147439
  • ENST00000519513
  • ENSP00000430423
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
virus perturbation
0.88
tissue sample
0.72
histone modification site profile
0.64
transcription factor binding site profile
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.19   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 306   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.19   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 306   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (85)
SNX1
Tbio
Novelty:  0.01267973
p_int:  0.999999939
p_ni:  6.1e-8
Score:  0.336
Data Source:  BioPlex,STRINGDB
FBXO8
Tbio
Novelty:  0.00682751
p_int:  0.999980272
p_wrong:  0.000019728
Score:  0.409
Data Source:  BioPlex,STRINGDB
PCM1
Tbio
Novelty:  0.02901589
p_int:  0.999874192
p_ni:  0.000125808
Data Source:  BioPlex
SNX5
Tbio
Novelty:  0.04075649
p_int:  0.999726834
p_ni:  0.000273166
Score:  0.558
Data Source:  BioPlex,STRINGDB
PICK1
Tbio
Novelty:  0.0058265
p_int:  0.999138344
p_ni:  0.000861631
p_wrong:  2.5e-8
Score:  0.193
Data Source:  BioPlex,STRINGDB
PEX11B
Tbio
Novelty:  0.04285427
p_int:  0.998650648
p_ni:  0.000919302
p_wrong:  0.00043005
Score:  0.237
Data Source:  BioPlex,STRINGDB
COG1
Tbio
Novelty:  0.0124285
p_int:  0.996342232
p_ni:  0.003657768
Score:  0.167
Data Source:  BioPlex,STRINGDB
GTF3C6
Tdark
Novelty:  1.44154731
p_int:  0.980279076
p_ni:  0.010583883
p_wrong:  0.009137042
Score:  0.319
Data Source:  BioPlex,STRINGDB
NME2P1
Tdark
Family:  Kinase
p_int:  0.975764014
p_ni:  0.024235972
p_wrong:  1.4e-8
Data Source:  BioPlex
COG7
Tbio
Novelty:  0.07137701
p_int:  0.973319513
p_ni:  0.026680413
p_wrong:  7.4e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
74.5
platelet count
1
1
1
73.9
platelet crit
1
1
1
73
glomerular filtration rate
2
2
2
70.4
creatinine measurement
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
74.5
platelet count
1
73.9
platelet crit
1
73
glomerular filtration rate
2
70.4
creatinine measurement
1
58.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bridging integrator 3
VGNC:11959
100615487
Macaque
bridging integrator 3
708840
Mouse
MGI:1929883
57784
Rat
RGD:1308253
361065
Dog
bridging integrator 3
608969
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bridging integrator 3
Macaque
bridging integrator 3
Mouse
Rat
Dog
bridging integrator 3
Publication Statistics
PubMed Score 45.19
PubMed score by year
PubTator Score 8.56
PubTator score by year
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Related Publications
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PMID
Year
Title