Tbio BIN3 Bridging integrator 3

Protein Summary

Description

Involved in cytokinesis and septation where it has a role in the localization of F-actin. The product of this gene is a member of the BAR domain protein family. The encoded protein is comprised solely of a BAR domain which is predicted to form coiled-coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of other processes. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NQY0
• Q9BVG2
• Q9NVY9

Gene Name

• BIN3

Ensembl ID

• ENST00000276416
• ENSP00000276416
• ENSG00000147439
• ENST00000519513
• ENSP00000430423

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.91
virus perturbation	0.88
tissue sample	0.72
histone modification site profile	0.64
transcription factor binding site profile	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.73   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 306   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.73   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 306   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0