Tbio BIN2 Bridging integrator 2

Protein Summary

Description

Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis.

Uniprot Accession IDs

• Q9UBW5
• B7Z6F3
• F5H0W4
• Q86VV0
• Q9NWK4
• Q9UKN4

Gene Name

• BIN2

Ensembl ID

• ENST00000544402
• ENSP00000445874
• ENSG00000110934

Symbol

• BRAP1
• BRAP-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.64
tissue sample	0.63
protein domain	0.58
co-expressed gene	0.52
cell line	0.46

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 262.7   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 262.7   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0