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Tbio
BIN1
Myc box-dependent-interacting protein 1

Protein Summary
Description
Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (PubMed:8782822). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed:28893863). This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor sup ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259238
  • ENSP00000259238
  • ENSG00000136717
  • ENST00000316724
  • ENSP00000316779
  • ENST00000346226
  • ENSP00000315411
  • ENST00000348750
  • ENSP00000259237
  • ENST00000351659
  • ENSP00000315388
  • ENST00000352848
  • ENSP00000315284
  • ENST00000357970
  • ENSP00000350654
  • ENST00000376113
  • ENSP00000365281
  • ENST00000393040
  • ENSP00000376760
  • ENST00000393041
  • ENSP00000376761
  • ENST00000409400
  • ENSP00000386797

Symbol
  • AMPHL
  • CNM2
  • AMPH2
  • AMPHL
  • SH3P9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor perturbation
0.98
disease perturbation
0.96
PubMedID
0.92
interacting protein
0.9


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 461.12   (req: < 5)
Gene RIFs: 103   (req: <= 3)
Antibodies: 390   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 461.12   (req: >= 5)
Gene RIFs: 103   (req: > 3)
Antibodies: 390   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (291)
BIN2
Tbio
Novelty:  0.00952157
p_int:  1
Score:  0.988
Data Source:  BioPlex,STRINGDB
AMPH
Tbio
Novelty:  0.00201043
p_int:  0.999999998
p_ni:  2e-9
Score:  0.97
Data Source:  BioPlex,Reactome,STRINGDB
Q6EEV4
Tbio
Family:  Enzyme
Novelty:  0.11413088
p_int:  0.999970042
p_ni:  0.000029957
p_wrong:  1e-9
Data Source:  BioPlex
NCAPD3
Tbio
Novelty:  0.02819003
p_int:  0.999511676
p_ni:  0.000488321
p_wrong:  3e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
DGUOK
Tbio
Family:  Kinase
Novelty:  0.00897987
p_int:  0.837835165
p_ni:  0.027917655
p_wrong:  0.13424718
Score:  0.193
Data Source:  BioPlex,STRINGDB
NUFIP1
Tbio
Novelty:  0.11726869
p_int:  0.837835165
p_ni:  0.027917655
p_wrong:  0.13424718
Data Source:  BioPlex
MYC
Tchem
Family:  TF
Novelty:  0.00005734
Score:  0.991
Data Source:  STRINGDB
PICALM
Tbio
Novelty:  0.00800832
Score:  0.99
Data Source:  STRINGDB
DNM2
Tchem
Novelty:  0.00265965
Score:  0.982
Data Source:  STRINGDB
WASL
Tbio
Novelty:  0.0029314
Score:  0.979
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (27)
Clathrin-mediated endocytosis (R-HSA-8856828)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Clathrin-mediated endocytosis
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (45)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
WormBase
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
AgBase
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ARUK-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Alzheimer disease
15
6
0
1.2
99.3
family history of Alzheimer’s disease
5
2
0
1.1
95.6
educational attainment
2
2
1
119.9
79.8
neutrophil count
3
3
3
58.9
blood protein measurement
2
2
2
51.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Alzheimer disease
0
1.2
99.3
family history of Alzheimer’s disease
0
1.1
95.6
educational attainment
1
119.9
79.8
neutrophil count
3
58.9
blood protein measurement
2
51.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
bridging integrator 1
713587
Mouse
MGI:108092
30948
Rat
RGD:621786
117028
Dog
bridging integrator 1
VGNC:38458
483870
Horse
bridging integrator 1
VGNC:15830
100052213
Species
Name
OMA
EggNOG
Inparanoid
Macaque
bridging integrator 1
Mouse
Rat
Dog
bridging integrator 1
Horse
bridging integrator 1
Publication Statistics
PubMed Score 461.12
PubMed score by year
PubTator Score 164.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title