Tbio BID BH3-interacting domain death agonist

Protein Summary

Description

The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2. This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P55957
• Q549M7
• Q71T04
• Q7Z4M9
• Q8IY86

Gene Name

• BID

Ensembl ID

• ENST00000317361
• ENSP00000318822
• ENSG00000015475
• ENST00000342111
• ENSP00000344594
• ENST00000399765
• ENSP00000382667
• ENST00000399767
• ENSP00000382669
• ENST00000399774
• ENSP00000382674
• ENST00000551952
• ENSP00000449236
• ENST00000611040
• ENSP00000483709
• ENST00000614949
• ENSP00000477773
• ENST00000615414
• ENSP00000483534
• ENST00000622694
• ENSP00000480414

Symbol

• FP497

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	1
biological process	0.98
virus perturbation	0.98
transcription factor perturbation	0.97
kinase perturbation	0.93

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.25   (req: < 5)

Gene RIFs: 154   (req: <= 3)

Antibodies: 1203   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.25   (req: >= 5)

Gene RIFs: 154   (req: > 3)

Antibodies: 1203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0