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Tchem
BHMT2
S-methylmethionine--homocysteine S-methyltransferase BHMT2

Protein Summary
Description
Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor. Homocysteine is a sulfur-containing amino acid that plays a crucial role in methylation reactions. Transfer of the methyl group from betaine to homocysteine creates methionine, which donates the methyl group to methylate DNA, proteins, lipids, and other intracellular metabolites. The protein encoded by this gene is one of two methyl transferases that can catalyze the transfer of the methyl group from betaine to homocysteine. Anomalies in homocysteine metabolism have been implicated in disorders ranging from vascular disease to neural tube birth defects such as spina bifida. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255192
  • ENSP00000255192
  • ENSG00000132840
  • ENST00000521567
  • ENSP00000430278
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.58
PubMedID
0.58
cell type or tissue
0.57
molecular function
0.56
microRNA
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.26   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.26   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (45)
BHMT
Tchem
Family:  Enzyme
Novelty:  0.00453508
p_int:  1
Score:  0.955
Data Source:  BioPlex,STRINGDB
TBCE
Tbio
Novelty:  0.01058281
p_int:  0.999998872
p_ni:  0.000001128
Score:  0.467
Data Source:  BioPlex,STRINGDB
INPPL1
Tchem
Family:  Enzyme
Novelty:  0.00634126
p_int:  0.999263155
p_ni:  0.000736845
Score:  0.253
Data Source:  BioPlex,STRINGDB
CBSL
Tdark
Novelty:  0.00062189
Score:  0.965
Data Source:  STRINGDB
MAT1A
Tbio
Family:  Enzyme
Novelty:  0.00384796
Score:  0.964
Data Source:  STRINGDB
MAT2A
Tchem
Family:  Enzyme
Novelty:  0.00667707
Score:  0.962
Data Source:  STRINGDB
AHCY
Tchem
Family:  Enzyme
Novelty:  0.00171812
Score:  0.959
Data Source:  STRINGDB
MAT2B
Tbio
Family:  Enzyme
Novelty:  0.04553044
Score:  0.952
Data Source:  STRINGDB
AHCYL2
Tbio
Family:  Enzyme
Novelty:  0.08695339
Score:  0.947
Data Source:  STRINGDB
CTH
Tchem
Family:  Enzyme
Novelty:  0.0017155
Score:  0.926
Data Source:  STRINGDB
Pathways (28)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Sulfur amino acid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Sulfur amino acid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
selenium measurement
1
3
3
83.1
serum selenium measurement
1
1
1
78.5
2
2
1
1.1
76.2
blood metabolite measurement
1
1
1
71.9
plasma betaine measurement
1
1
1
56.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
selenium measurement
3
83.1
serum selenium measurement
1
78.5
1
1.1
76.2
blood metabolite measurement
1
71.9
plasma betaine measurement
1
56.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
betaine--homocysteine S-methyltransferase 2
VGNC:6382
471829
Macaque
betaine--homocysteine S-methyltransferase 2
714308
Mouse
MGI:1891379
64918
Rat
RGD:1359418
365972
Dog
betaine--homocysteine S-methyltransferase 2
VGNC:38448
488934
Species
Name
OMA
EggNOG
Inparanoid
Chimp
betaine--homocysteine S-methyltransferase 2
Macaque
betaine--homocysteine S-methyltransferase 2
Mouse
Rat
Dog
betaine--homocysteine S-methyltransferase 2
Publication Statistics
PubMed Score 11.26
PubMed score by year
PubTator Score 7.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title