BHMT2
S-methylmethionine--homocysteine S-methyltransferase BHMT2
Protein Summary
Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor. Homocysteine is a sulfur-containing amino acid that plays a crucial role in methylation reactions. Transfer of the methyl group from betaine to homocysteine creates methionine, which donates the methyl group to methylate DNA, proteins, lipids, and other intracellular metabolites. The protein encoded by this gene is one of two methyl transferases that can catalyze the transfer of the methyl group from betaine to homocysteine. Anomalies in homocysteine metabolism have been implicated in disorders ranging from vascular disease to neural tube birth defects such as spina bifida. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
- ENST00000255192
- ENSP00000255192
- ENSG00000132840
- ENST00000521567
- ENSP00000430278
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.58 | ||
PubMedID | 0.58 | ||
cell type or tissue | 0.57 | ||
molecular function | 0.56 | ||
microRNA | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.26 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 108 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.26 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 108 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (45)
TBCE
Novelty: 0.01058281
p_int: 0.999998872
p_ni: 0.000001128
Score: 0.467
Data Source: BioPlex,STRINGDB
INPPL1
Family: Enzyme
Novelty: 0.00634126
p_int: 0.999263155
p_ni: 0.000736845
Score: 0.253
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (2)
Downstream (2)
1 – 2 of 2
Pathways (28)
Reactome (3)
KEGG (2)
UniProt (1)
WikiPathways (22)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Reactome | Sulfur amino acid metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of amino acids and derivatives | ||||
Sulfur amino acid metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (3)
Components (2)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
selenium measurement | 1 | 3 | 3 | 83.1 | |||||
serum selenium measurement | 1 | 1 | 1 | 78.5 | |||||
2 | 2 | 1 | 1.1 | 76.2 | |||||
blood metabolite measurement | 1 | 1 | 1 | 71.9 | |||||
plasma betaine measurement | 1 | 1 | 1 | 56.4 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
selenium measurement | 3 | 83.1 | |||||
serum selenium measurement | 1 | 78.5 | |||||
1 | 1.1 | 76.2 | |||||
blood metabolite measurement | 1 | 71.9 | |||||
plasma betaine measurement | 1 | 56.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | betaine--homocysteine S-methyltransferase 2 | VGNC:6382 | 471829 | |||||
Macaque | betaine--homocysteine S-methyltransferase 2 | 714308 | ||||||
Mouse | MGI:1891379 | 64918 | ||||||
Rat | RGD:1359418 | 365972 | ||||||
Dog | betaine--homocysteine S-methyltransferase 2 | VGNC:38448 | 488934 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | betaine--homocysteine S-methyltransferase 2 | |||||
Macaque | betaine--homocysteine S-methyltransferase 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | betaine--homocysteine S-methyltransferase 2 | |||||
Publication Statistics
PubMed Score 11.26
PubMed score by year
PubTator Score 7.99
PubTator score by year
Related Publications
Text Mined References (31)
GeneRif Annotations (15)
Items per page:
0 of 0
PMID | Year | Title |
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