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Tchem
BHMT
Betaine--homocysteine S-methyltransferase 1

Protein Summary
Description
Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline. This gene encodes a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in this gene could lead to hyperhomocyst(e)inemia, but such a defect has not yet been observed. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274353
  • ENSP00000274353
  • ENSG00000145692

Symbol
  • BHMT1
  • HEL-S-61p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.69
disease
0.69
PubMedID
0.68
gene perturbation
0.67
kinase perturbation
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 240.41   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 423   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 240.41   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 423   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (8)
Protein-Protein Interactions (82)
BHMT2
Tchem
Family:  Enzyme
Novelty:  0.07713739
p_int:  1
Score:  0.955
Data Source:  BioPlex,STRINGDB
MTMR6
Tbio
Family:  Enzyme
Novelty:  0.13067072
p_int:  0.976776164
p_ni:  0.020552626
p_wrong:  0.00267121
Score:  0.282
Data Source:  BioPlex,STRINGDB
CBSL
Tdark
Novelty:  0.00062189
Score:  0.982
Data Source:  STRINGDB
MAT1A
Tbio
Family:  Enzyme
Novelty:  0.00384796
Score:  0.978
Data Source:  STRINGDB
AHCY
Tchem
Family:  Enzyme
Novelty:  0.00171812
Score:  0.978
Data Source:  STRINGDB
DMGDH
Tbio
Family:  Enzyme
Novelty:  0.03936436
Score:  0.976
Data Source:  STRINGDB
MAT2A
Tchem
Family:  Enzyme
Novelty:  0.00667707
Score:  0.974
Data Source:  STRINGDB
MAT2B
Tbio
Family:  Enzyme
Novelty:  0.04553044
Score:  0.966
Data Source:  STRINGDB
CTH
Tchem
Family:  Enzyme
Novelty:  0.0017155
Score:  0.961
Data Source:  STRINGDB
AHCYL2
Tbio
Family:  Enzyme
Novelty:  0.08695339
Score:  0.957
Data Source:  STRINGDB
Pathways (19)
Choline catabolism (R-HSA-6798163)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Choline catabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Sulfur amino acid metabolism
Name
Explore in Pharos
Explore in Source
Choline catabolism
Metabolism
Metabolism of amino acids and derivatives
Sulfur amino acid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
selenium measurement
1
3
3
83.1
serum selenium measurement
1
1
1
78.5
2
2
1
1.1
76.2
blood metabolite measurement
1
1
1
71.9
plasma betaine measurement
1
1
1
56.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
selenium measurement
3
83.1
serum selenium measurement
1
78.5
1
1.1
76.2
blood metabolite measurement
1
71.9
plasma betaine measurement
1
56.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
betaine--homocysteine S-methyltransferase
714363
Mouse
MGI:1339972
12116
Mouse
MGI:3643681
329008
Rat
RGD:621496
81508
Dog
betaine--homocysteine S-methyltransferase
VGNC:38447
479171
Species
Name
OMA
EggNOG
Inparanoid
Macaque
betaine--homocysteine S-methyltransferase
Mouse
Mouse
Rat
Dog
betaine--homocysteine S-methyltransferase
Publication Statistics
PubMed Score 240.41
PubMed score by year
PubTator Score 89.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title