Tbio BHLHE22 Class E basic helix-loop-helix protein 22

Protein Summary

Description

Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal chord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation. This gene encodes a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors that regulate cell fate determination, proliferation, and differentiation. A similar protein in mouse is required for the development of the dorsal cochlear nuclei, and is thought to play a role in in the differentiation of neurons involved in sensory input. The mouse protein also functions in retinogenesis. [provided by RefSeq, Oct 2016]

Uniprot Accession IDs

• Q8NFJ8
• bHLHe22

Gene Name

• BHLHE22

Ensembl ID

• ENST00000321870
• ENSP00000318799
• ENSG00000180828

Symbol

• BHLHB5
• TNRC20
• Beta3
• BHLHB5
• Beta3a
• CAGL85
• TNRC20

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.68
PubMedID	0.61
cell line	0.6
gene perturbation	0.55
microRNA	0.51

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Class E Basic Helix-loop-helix Protein 22

Protein / Nucleic Acid Binding / Nuclease / Class E Basic Helix-loop-helix Protein 22

DTO Classes

Protein / Enzyme / Nuclease / Class E Basic Helix-loop-helix Protein 22

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.57   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 138   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.57   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0