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Tbio
BHLHE22
Class E basic helix-loop-helix protein 22

Protein Summary
Description
Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal chord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation. This gene encodes a protein that belongs ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321870
  • ENSP00000318799
  • ENSG00000180828

Symbol
  • BHLHB5
  • TNRC20
  • Beta3
  • BHLHB5
  • Beta3a
  • CAGL85
  • TNRC20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.68
PubMedID
0.61
cell line
0.6
gene perturbation
0.55
microRNA
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.57   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.57   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
ADRB3
Tclin
Family:  GPCR
Novelty:  0.00128102
Score:  0.794
Data Source:  STRINGDB
PRDM8
Tbio
Family:  TF; Epigenetic
Novelty:  0.08003201
Score:  0.779
Data Source:  STRINGDB
TUBB4A
Tclin
Novelty:  0.00045092
Score:  0.741
Data Source:  STRINGDB
ADRA2B
Tclin
Family:  GPCR
Novelty:  0.00633206
Score:  0.712
Data Source:  STRINGDB
ADRB1
Tclin
Family:  GPCR
Novelty:  0.00111668
Score:  0.707
Data Source:  STRINGDB
BARHL2
Tbio
Family:  TF
Novelty:  0.09447868
Score:  0.699
Data Source:  STRINGDB
ADRA2A
Tclin
Family:  GPCR
Novelty:  0.00273659
Score:  0.695
Data Source:  STRINGDB
ADRA2C
Tclin
Family:  GPCR
Novelty:  0.00661399
Score:  0.695
Data Source:  STRINGDB
ADRA1B
Tclin
Family:  GPCR
Novelty:  0.00381271
Score:  0.693
Data Source:  STRINGDB
ADRA1A
Tclin
Family:  GPCR
Novelty:  0.00379919
Score:  0.686
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
5
4
4
1
93.5
2
1
1
1
78.6
neuroticism measurement
3
3
1
5.7
72.4
risky sexual behaviour measurement
1
1
1
70.1
wellbeing measurement
1
1
1
52.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
4
1
93.5
1
1
78.6
neuroticism measurement
1
5.7
72.4
risky sexual behaviour measurement
1
70.1
wellbeing measurement
1
52.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1930001
59058
Rat
RGD:1305451
365748
Opossum
basic helix-loop-helix family member e22 [Source:HGNC Symbol;Acc:HGNC:11963]
Anole lizard
basic helix-loop-helix family member e22
100552717
Zebrafish
ZDB-GENE-040426-1411
393930
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Opossum
basic helix-loop-helix family member e22 [Source:HGNC Symbol;Acc:HGNC:11963]
Anole lizard
basic helix-loop-helix family member e22
Zebrafish
Publication Statistics
PubMed Score 131.57
PubMed score by year
PubTator Score 28.17
PubTator score by year
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Related Publications
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PMID
Year
Title