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Tbio
BHLHA15
Class A basic helix-loop-helix protein 15

Protein Summary
Description
Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314018
  • ENSP00000326391
  • ENSG00000180535
  • ENST00000609256
  • ENSP00000476312

Symbol
  • BHLHB8
  • MIST1
  • MIST1
  • BHLHB8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.89
molecular function
0.73
phenotype
0.49
transcription factor
0.48
metabolite
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.9   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.9   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
HIST1H1C
Tbio
Novelty:  0.00415337
p_int:  0.999981999
p_ni:  0.000018001
Data Source:  BioPlex
CHCHD2
Tbio
Novelty:  0.01615338
p_int:  0.999975632
p_ni:  5.6e-8
p_wrong:  0.000024312
Score:  0.165
Data Source:  BioPlex,STRINGDB
PARP12
Tchem
Family:  Enzyme
Novelty:  0.08076657
p_int:  0.999945525
p_ni:  0.000054475
Data Source:  BioPlex
FAF1
Tbio
Novelty:  0.01526275
p_int:  0.999944932
p_ni:  0.000055068
Data Source:  BioPlex
RNF41
Tbio
Family:  Enzyme
Novelty:  0.01953473
p_int:  0.999764881
p_ni:  0.000234981
p_wrong:  1.38e-7
Data Source:  BioPlex
PHF10
Tbio
Family:  Epigenetic
Novelty:  0.05941323
p_int:  0.999724335
p_ni:  0.000275665
Data Source:  BioPlex
C1QBP
Tbio
Novelty:  0.00532825
p_int:  0.999643068
p_ni:  0.000356932
Data Source:  BioPlex
HIST1H1T
Tdark
Novelty:  0.01039464
p_int:  0.999203877
p_ni:  0.000796121
p_wrong:  2e-9
Data Source:  BioPlex
RPS27A
Tbio
Novelty:  0.00658124
p_int:  0.998235615
p_ni:  0.001764385
Data Source:  BioPlex
BAG1
Tbio
Novelty:  0.00285515
p_int:  0.998150378
p_ni:  0.001798427
p_wrong:  0.000051195
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
2
4
95.9
testosterone measurement
2
2
2
92.8
4
2
0
1.1
91.4
urate measurement
2
2
2
80.6
lymphocyte percentage of leukocytes
1
1
1
72.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
95.9
testosterone measurement
2
92.8
0
1.1
91.4
urate measurement
2
80.6
lymphocyte percentage of leukocytes
1
72.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
basic helix-loop-helix family member a15
VGNC:13633
472455
Mouse
MGI:891976
17341
Rat
RGD:3091
25334
Dog
basic helix-loop-helix family member a15
VGNC:38444
489869
Opossum
basic helix-loop-helix family member a15
100027492
Species
Name
OMA
EggNOG
Inparanoid
Chimp
basic helix-loop-helix family member a15
Mouse
Rat
Dog
basic helix-loop-helix family member a15
Opossum
basic helix-loop-helix family member a15
Publication Statistics
PubMed Score 36.90
PubMed score by year
PubTator Score 21.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title