Tbio BGN Biglycan

Protein Summary

Description

May be involved in collagen fiber assembly. This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• P21810
• D3DWU3
• P13247

Gene Name

• BGN

Ensembl ID

• ENST00000331595
• ENSP00000327336
• ENSG00000182492

Symbol

• SLRR1A
• PGI
• MRLS
• DSPG1
• PG-S1
• SEMDX
• SLRR1A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
disease perturbation	0.97
cellular component	0.89
small molecule perturbation	0.82
gene perturbation	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 856.89   (req: < 5)

Gene RIFs: 101   (req: <= 3)

Antibodies: 371   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 856.89   (req: >= 5)

Gene RIFs: 101   (req: > 3)

Antibodies: 371   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0