You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
BFSP2
Phakinin

Protein Summary
Description
Involved in stabilization of lens fiber cell cytoskeleton. More than 99% of the vertebrate ocular lens is comprised of terminally differentiated lens fiber cells. Two lens-specific intermediate filament-like proteins, the protein product of this gene (phakinin), and filensin, are expressed only after fiber cell differentiation has begun. Both proteins are found in a structurally unique cytoskeletal element that is referred to as the beaded filament (BF). Mutations in this gene have been associated with juvenile-onset, progressive cataracts and Dowling-Meara epidermolysis bullosa simplex. [provided by RefSeq, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302334
  • ENSP00000304987
  • ENSG00000170819

Symbol
  • CP47
  • CP49
  • LIFL-L
  • CTRCT12
  • PHAKOSIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.56
gene perturbation
0.53
cell line
0.52
disease
0.46
trait
0.46


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 499.44   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 499.44   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
BFSP1
Tbio
Novelty:  0.01519136
p_int:  0.999999991
p_ni:  2e-9
p_wrong:  7e-9
Score:  0.968
Data Source:  BioPlex,STRINGDB
TRIP11
Tbio
Novelty:  0.03011344
p_int:  0.999999922
p_ni:  7.3e-8
p_wrong:  5e-9
Score:  0.214
Data Source:  BioPlex,STRINGDB
NEK2
Tchem
Family:  Kinase
Novelty:  0.0059613
p_int:  0.999999624
p_ni:  2.42e-7
p_wrong:  1.34e-7
Score:  0.243
Data Source:  BioPlex,STRINGDB
CDR2L
Tbio
Novelty:  0.09295886
p_int:  0.999999334
p_ni:  6.66e-7
Score:  0.214
Data Source:  BioPlex,STRINGDB
CENPE
Tchem
Novelty:  0.00458125
p_int:  0.999998843
p_ni:  0.000001157
Score:  0.332
Data Source:  BioPlex,STRINGDB
SUFU
Tbio
Novelty:  0.00475249
p_int:  0.999984806
p_ni:  0.000015194
Data Source:  BioPlex
CALCOCO1
Tbio
Novelty:  0.17497928
p_int:  0.999965477
p_ni:  0.000034523
Score:  0.173
Data Source:  BioPlex,STRINGDB
MAX
Tbio
Family:  TF
Novelty:  0.00799068
p_int:  0.999570704
p_ni:  0.000429296
Score:  0.188
Data Source:  BioPlex,STRINGDB
TRIM11
Tbio
Family:  Enzyme
Novelty:  0.02243955
p_int:  0.996822718
p_ni:  0.003177282
Data Source:  BioPlex
CEP44
Tdark
Novelty:  1.20621472
p_int:  0.996388824
p_ni:  0.003611159
p_wrong:  1.7e-8
Score:  0.204
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
daytime rest measurement
1
1
1
35
chronotype measurement
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
daytime rest measurement
1
35
chronotype measurement
1
29
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
beaded filament structural protein 2
VGNC:6167
460708
Macaque
beaded filament structural protein 2
717551
Mouse
MGI:1333828
107993
Rat
RGD:1591927
501046
Dog
beaded filament structural protein 2
VGNC:38441
608938
Species
Name
OMA
EggNOG
Inparanoid
Chimp
beaded filament structural protein 2
Macaque
beaded filament structural protein 2
Mouse
Rat
Dog
beaded filament structural protein 2
Publication Statistics
PubMed Score 499.44
PubMed score by year
PubTator Score 136.25
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title