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Tbio
BFSP1
Filensin

Protein Summary
Description
This gene encodes a lens-specific intermediate filament-like protein named filensin. The encoded protein is expressed in lens fiber cells after differentiation has begun. This protein functions as a component of the beaded filament which is a cytoskeletal structure found in lens fiber cells. Mutations in this gene are the cause of autosomal recessive cortical juvenile-onset cataract. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377868
  • ENSP00000367099
  • ENSG00000125864
  • ENST00000377873
  • ENSP00000367104
  • ENST00000536626
  • ENSP00000442522

Symbol
  • CP94
  • CP115
  • LIFL-H
  • CTRCT33
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.68
gene perturbation
0.65
small molecule perturbation
0.62
trait
0.61
cell line
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.08   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.08   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
BFSP2
Tbio
Novelty:  0.00206411
p_int:  0.999999991
p_ni:  2e-9
p_wrong:  7e-9
Score:  0.968
Data Source:  BioPlex,STRINGDB
CCDC18
Tdark
Novelty:  0.61246881
p_int:  0.999999978
p_ni:  2.2e-8
Data Source:  BioPlex
C16orf45
Tbio
Novelty:  0.00913059
p_int:  0.999999868
p_ni:  1.32e-7
Score:  0.187
Data Source:  BioPlex,STRINGDB
PIBF1
Tbio
Novelty:  0.0454209
p_int:  0.9999989
p_ni:  0.000001099
p_wrong:  1e-9
Data Source:  BioPlex
CCDC92
Tbio
Novelty:  0.32125749
p_int:  0.999998552
p_ni:  0.000001432
p_wrong:  1.6e-8
Data Source:  BioPlex
MPHOSPH9
Tbio
Family:  Enzyme
Novelty:  0.06682688
p_int:  0.999998367
p_ni:  0.000001318
p_wrong:  3.16e-7
Data Source:  BioPlex
NUP54
Tbio
Novelty:  0.08155008
p_int:  0.999997601
p_ni:  0.000002398
p_wrong:  1e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
CIT
Tchem
Family:  Kinase
Novelty:  0.04094716
p_int:  0.999997423
p_ni:  0.000002577
Data Source:  BioPlex
TRIM9
Tbio
Family:  Enzyme
Novelty:  0.06250762
p_int:  0.999965371
p_ni:  0.000030169
p_wrong:  0.000004461
Data Source:  BioPlex
CEP63
Tbio
Novelty:  0.08869992
p_int:  0.999937192
p_ni:  0.000062798
p_wrong:  1e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
2
2
84.1
apolipoprotein A 1 measurement
2
1
2
77.7
high density lipoprotein cholesterol measurement
2
1
2
67.1
myeloperoxidase measurement
1
1
1
64.9
eosinophil percentage of leukocytes
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
84.1
apolipoprotein A 1 measurement
2
77.7
high density lipoprotein cholesterol measurement
2
67.1
myeloperoxidase measurement
1
64.9
eosinophil percentage of leukocytes
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
beaded filament structural protein 1
VGNC:6051
458107
Macaque
beaded filament structural protein 1
695840
Mouse
MGI:101770
12075
Rat
RGD:2205
25394
Dog
beaded filament structural protein 1
VGNC:38440
485756
Species
Name
OMA
EggNOG
Inparanoid
Chimp
beaded filament structural protein 1
Macaque
beaded filament structural protein 1
Mouse
Rat
Dog
beaded filament structural protein 1
Publication Statistics
PubMed Score 66.08
PubMed score by year
PubTator Score 55.43
PubTator score by year
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Related Publications
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PMID
Year
Title