Protein Summary
This gene encodes a lens-specific intermediate filament-like protein named filensin. The encoded protein is expressed in lens fiber cells after differentiation has begun. This protein functions as a component of the beaded filament which is a cytoskeletal structure found in lens fiber cells. Mutations in this gene are the cause of autosomal recessive cortical juvenile-onset cataract. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
- ENST00000377868
- ENSP00000367099
- ENSG00000125864
- ENST00000377873
- ENSP00000367104
- ENST00000536626
- ENSP00000442522
- CP94
- CP115
- LIFL-H
- CTRCT33
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cellular component | 0.68 | ||
gene perturbation | 0.65 | ||
small molecule perturbation | 0.62 | ||
trait | 0.61 | ||
cell line | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 66.08 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 232 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 66.08 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 232 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (86)
BFSP2
Novelty: 0.00206411
p_int: 0.999999991
p_ni: 2e-9
p_wrong: 7e-9
Score: 0.968
Data Source: BioPlex,STRINGDB
C16orf45
Novelty: 0.00913059
p_int: 0.999999868
p_ni: 1.32e-7
Score: 0.187
Data Source: BioPlex,STRINGDB
CCDC92
Novelty: 0.32125749
p_int: 0.999998552
p_ni: 0.000001432
p_wrong: 1.6e-8
Data Source: BioPlex
MPHOSPH9
Family: Enzyme
Novelty: 0.06682688
p_int: 0.999998367
p_ni: 0.000001318
p_wrong: 3.16e-7
Data Source: BioPlex
NUP54
Novelty: 0.08155008
p_int: 0.999997601
p_ni: 0.000002398
p_wrong: 1e-9
Score: 0.188
Data Source: BioPlex,STRINGDB
CIT
Family: Kinase
Novelty: 0.04094716
p_int: 0.999997423
p_ni: 0.000002577
Data Source: BioPlex
TRIM9
Family: Enzyme
Novelty: 0.06250762
p_int: 0.999965371
p_ni: 0.000030169
p_wrong: 0.000004461
Data Source: BioPlex
CEP63
Novelty: 0.08869992
p_int: 0.999937192
p_ni: 0.000062798
p_wrong: 1e-8
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (2)
Components (3)
Processes (2)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
eosinophil count | 2 | 2 | 2 | 84.1 | |||||
apolipoprotein A 1 measurement | 2 | 1 | 2 | 77.7 | |||||
high density lipoprotein cholesterol measurement | 2 | 1 | 2 | 67.1 | |||||
myeloperoxidase measurement | 1 | 1 | 1 | 64.9 | |||||
eosinophil percentage of leukocytes | 1 | 1 | 1 | 44.2 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
eosinophil count | 2 | 84.1 | |||||
apolipoprotein A 1 measurement | 2 | 77.7 | |||||
high density lipoprotein cholesterol measurement | 2 | 67.1 | |||||
myeloperoxidase measurement | 1 | 64.9 | |||||
eosinophil percentage of leukocytes | 1 | 44.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | beaded filament structural protein 1 | VGNC:6051 | 458107 | |||||
Macaque | beaded filament structural protein 1 | 695840 | ||||||
Mouse | MGI:101770 | 12075 | ||||||
Rat | RGD:2205 | 25394 | ||||||
Dog | beaded filament structural protein 1 | VGNC:38440 | 485756 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | beaded filament structural protein 1 | |||||
Macaque | beaded filament structural protein 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | beaded filament structural protein 1 | |||||
Publication Statistics
PubMed Score 66.08
PubMed score by year
PubTator Score 55.43
PubTator score by year
Related Publications
Text Mined References (19)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
---|