Tbio BFSP1 Filensin

Protein Summary

Description

This gene encodes a lens-specific intermediate filament-like protein named filensin. The encoded protein is expressed in lens fiber cells after differentiation has begun. This protein functions as a component of the beaded filament which is a cytoskeletal structure found in lens fiber cells. Mutations in this gene are the cause of autosomal recessive cortical juvenile-onset cataract. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• Q12934
• F5H0G1
• O43595
• O76034
• O95676
• Q8IVZ6
• Q9HBX4

Gene Name

• BFSP1

Ensembl ID

• ENST00000377868
• ENSP00000367099
• ENSG00000125864
• ENST00000377873
• ENSP00000367104
• ENST00000536626
• ENSP00000442522

Symbol

• CP94
• CP115
• LIFL-H
• CTRCT33

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.68
gene perturbation	0.65
small molecule perturbation	0.62
trait	0.61
cell line	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.2   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 232   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.2   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0