Tdark BET1 BET1 homolog

Protein Summary

Description

Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane (By similarity). This gene encodes a golgi-associated membrane protein that participates in vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex. The encoded protein functions as a soluble N-ethylaleimide-sensitive factor attachment protein receptor and may be involved in the docking of ER-derived vesicles with the cis-Golgi membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• O15155
• Q96EA0
• hBET1

Gene Name

• BET1

Ensembl ID

• ENST00000222547
• ENSP00000222547
• ENSG00000105829
• ENST00000433727
• ENSP00000391228

Symbol

• HBET1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.83
interacting protein	0.82
histone modification site profile	0.8
transcription factor binding site profile	0.78
cellular component	0.75

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Snare Protein / Bet1 Homolog

DTO Classes

Protein / Transporter / Snare Protein / Bet1 Homolog

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.74   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 34   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.74   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (200)

Explore Interacting Targets

1 – 10 of 200

• See Interactions on String-DB

SEC22B

Tbio

Novelty:  0.03035448

p_int:  0.999922949

p_ni:  0.000076954

p_wrong:  9.7e-8

Score:  0.995

Data Source:  BioPlex,Reactome,STRINGDB

STX18

Tbio

Novelty:  0.0259034

p_int:  0.999874073

p_ni:  0.000125869

p_wrong:  5.8e-8

Score:  0.926

Data Source:  BioPlex,STRINGDB

TRDN

Tbio

Novelty:  0.00501554

p_int:  0.9649414

p_ni:  0.034634219

p_wrong:  0.000424381

Data Source:  BioPlex

IL20RA

Tbio

Novelty:  0.02416816

p_int:  0.963180199

p_ni:  0.036324633

p_wrong:  0.000495168

Data Source:  BioPlex

IFT20

Tbio

Novelty:  0.03005088

p_int:  0.929150652

p_ni:  0.05874046

p_wrong:  0.012108889

Data Source:  BioPlex

CHRNB1

Tclin

Family:  IC

Novelty:  0.04777051

p_int:  0.927043188

p_ni:  0.058027908

p_wrong:  0.014928903

Data Source:  BioPlex

HAUS1

Tbio

Novelty:  0.11356375

p_int:  0.884023399

p_ni:  0.11541869

p_wrong:  0.000557911

Score:  0.173

Data Source:  BioPlex,STRINGDB

MANSC1

Tdark

Novelty:  0.91681036

p_int:  0.865997253

p_ni:  0.001801338

p_wrong:  0.132201409

Data Source:  BioPlex

COX4I1

Tbio

Family:  Enzyme

Novelty:  0.00208873

p_int:  0.864841576

p_ni:  0.008981119

p_wrong:  0.126177305

Data Source:  BioPlex

ADGRE5

Tbio

Family:  GPCR

Novelty:  0.01137558

p_int:  0.85609226

p_ni:  0.002282381

p_wrong:  0.141625359

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (10)

Reactome (9)

KEGG (1)

Asparagine N-linked glycosylation (R-HSA-446203)

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Find Similar Targets

Items per page:

5

1 – 5 of 9

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Asparagine N-linked glycosylation	286 targets	R-HSA-446203
Reactome	COPI-mediated anterograde transport	83 targets	R-HSA-6807878
Reactome	COPII-mediated vesicle transport	68 targets	R-HSA-204005
Reactome	ER to Golgi Anterograde Transport	136 targets	R-HSA-199977
Reactome	Membrane Trafficking	612 targets	R-HSA-199991

Name	Explore in Pharos	Explore in Source
Asparagine N-linked glycosylation	286 targets	R-HSA-446203
COPI-mediated anterograde transport	83 targets	R-HSA-6807878
COPII-mediated vesicle transport	68 targets	R-HSA-204005
ER to Golgi Anterograde Transport	136 targets	R-HSA-199977
Membrane Trafficking	612 targets	R-HSA-199991

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (9)

Components (6)

Processes (3)

Find Similar Targets

Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
membrane	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
endoplasmic reticulum-Golgi intermediate compartment membrane	Traceable Author Statement (TAS)	Reactome
Golgi membrane	Traceable Author Statement (TAS)	Reactome
transport vesicle	Traceable Author Statement (TAS)	Reactome
endoplasmic reticulum membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell
integral component of Golgi membrane	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heart rate variability measurement	EFO_0008003	3	2	6		75.9
heart rate response to recovery post exercise	EFO_0009185	5	2	5		57.6
heart rate	EFO_0004326	1	1	1		12.7

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heart rate variability measurement	EFO_0008003	6		75.9
heart rate response to recovery post exercise	EFO_0009185	5		57.6
heart rate	EFO_0004326	1		12.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Coiled coil
Complete proteome
Endoplasmic reticulum
ER-Golgi transport
Golgi apparatus
Membrane
Phosphoprotein
Protein transport

GWAS Trait Find Similar Targets

No Header	No Header
heart rate
heart rate response to recovery post exercise
heart rate variability measurement

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	Bet1 golgi vesicular membrane trafficking protein		700492
Mouse	Bet1 golgi vesicular membrane trafficking protein	MGI:1343104	12068
Rat	Bet1 golgi vesicular membrane trafficking protein	RGD:2203	29631
Cow	Bet1 golgi vesicular membrane trafficking protein	VGNC:26475	616526
Opossum	Bet1 golgi vesicular membrane trafficking protein [Source:HGNC Symbol;Acc:HGNC:14562]

Species	Name	OMA	EggNOG	Inparanoid
Macaque	Bet1 golgi vesicular membrane trafficking protein
Mouse	Bet1 golgi vesicular membrane trafficking protein
Rat	Bet1 golgi vesicular membrane trafficking protein
Cow	Bet1 golgi vesicular membrane trafficking protein
Opossum	Bet1 golgi vesicular membrane trafficking protein [Source:HGNC Symbol;Acc:HGNC:14562]

Publication Statistics

PubMed Score 51.74

PubMed score by year

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PubTator Score 126.97

PubTator score by year

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Related Publications

Text Mined References (19)

GeneRif Annotations (1)

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10

0 of 0

PMID	Year	Title