You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
BDP1
Transcription factor TFIIIB component B'' homolog

Protein Summary
Description
General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. The product of this gene is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase II during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358731
  • ENSP00000351575
  • ENSG00000145734
  • ENST00000617085
  • ENSP00000482469
  • ENSG00000273873

Symbol
  • KIAA1241
  • KIAA1689
  • TFNR
  • TFC5
  • TFNR
  • TAF3B1
  • DFNB112
  • TFIIIB''
  • TFIIIB90
  • HSA238520
  • TFIIIB150
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.72
cell type or tissue
0.68
cell line
0.66
histone modification site profile
0.64
transcription factor binding site profile
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 208.02   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 16   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 208.02   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 16   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (115)
BRF2
Tbio
Novelty:  0.39111125
Score:  0.999
Data Source:  Reactome,STRINGDB
BRF1
Tbio
Novelty:  0.03174992
Score:  0.997
Data Source:  Reactome,STRINGDB
TBP
Tbio
Novelty:  0.00034941
Score:  0.996
Data Source:  Reactome,STRINGDB
POLR3A
Tbio
Family:  Enzyme
Novelty:  0.01508849
Score:  0.996
Data Source:  STRINGDB
POLR3F
Tbio
Family:  Enzyme
Novelty:  0.0805125
Score:  0.994
Data Source:  STRINGDB
POLR3C
Tbio
Family:  Enzyme
Novelty:  0.05778457
Score:  0.991
Data Source:  STRINGDB
GTF3C1
Tbio
Novelty:  0.00580303
Score:  0.991
Data Source:  STRINGDB
P0DPB6
Tbio
Family:  Enzyme
Novelty:  0.01598347
Score:  0.987
Data Source:  STRINGDB
GTF3C3
Tdark
Novelty:  0.48547531
Score:  0.987
Data Source:  STRINGDB
POLR3D
Tbio
Family:  Enzyme
Novelty:  0.02616321
Score:  0.987
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase III Abortive And Retractive Initiation
Reactome
RNA Polymerase III Transcription
Reactome
RNA Polymerase III Transcription Initiation
Reactome
RNA Polymerase III Transcription Initiation From Type 1 Promoter
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase III Transcription
RNA Polymerase III Transcription Initiation
RNA Polymerase III Transcription Initiation From Type 1 Promoter
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
38.2
red blood cell distribution width
1
1
1
38.2
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
38.2
red blood cell distribution width
1
38.2
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 208.02
PubMed score by year
PubTator Score 72.53
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title