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Tclin
BDKRB2
B2 bradykinin receptor

Protein Summary
Description
Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000539359
  • ENSP00000438376
  • ENSG00000168398
  • ENST00000542454
  • ENSP00000439459
  • ENST00000554311
  • ENSP00000450482

Symbol
  • BKR2
  • B2R
  • BK2
  • BK-2
  • BKR2
  • BRB2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.92
molecular function
0.91
biological process
0.89
ligand (chemical)
0.8
PubMedID
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 359.37   (req: < 5)
Gene RIFs: 151   (req: <= 3)
Antibodies: 233   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 359.37   (req: >= 5)
Gene RIFs: 151   (req: > 3)
Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 308
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1