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Tbio
BDH1
D-beta-hydroxybutyrate dehydrogenase, mitochondrial

Protein Summary
Description
This gene encodes a member of the short-chain dehydrogenase/reductase gene family. The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement for phosphatidylcholine for optimal enzymatic activity. The encoded protein catalyzes the interconversion of acetoacetate and (R)-3-hydroxybutyrate, the two major ketone bodies produced during fatty acid catabolism. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358186
  • ENSP00000350914
  • ENSG00000161267
  • ENST00000392378
  • ENSP00000376183
  • ENST00000392379
  • ENSP00000376184
  • ENST00000612690
  • ENSP00000484421
  • ENSG00000275544
  • ENST00000617317
  • ENSP00000482744

Symbol
  • BDH
  • SDR9C1
  • BDH
  • SDR9C1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
metabolite
0.78
transcription factor perturbation
0.74
virus perturbation
0.72
small molecule perturbation
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.2   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 217   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.2   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0