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Tbio
BCS1L
Mitochondrial chaperone BCS1

Protein Summary
Description
Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. This gene encodes a homolog of the S. cerevisiae bcs1 protein which is involved in the assembly of complex III of the mitochondrial respiratory chain. The encoded protein does not contain a mitochondrial targeting sequence but experimental studies confirm that it is imported into mitochondria. Mutations in this gene are associated with mitochondrial complex III deficiency and the GRACILE syndrome. Several alternatively spliced transcripts encoding two different isoforms have been described. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359273
  • ENSP00000352219
  • ENSG00000074582
  • ENST00000392109
  • ENSP00000375957
  • ENST00000392110
  • ENSP00000375958
  • ENST00000392111
  • ENSP00000375959
  • ENST00000412366
  • ENSP00000406494
  • ENST00000431802
  • ENSP00000413908
  • ENST00000439945
  • ENSP00000404999

Symbol
  • BCS1
  • BCS
  • BJS
  • PTD
  • BCS1
  • FLNMS
  • h-BCS
  • MC3DN1
  • h-BCS1
  • GRACILE
  • Hs.6719
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.97
histone modification site profile
0.91
protein domain
0.85
disease perturbation
0.83
transcription factor binding site profile
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.78   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.78   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (200)
NRP1
Tchem
Novelty:  0.00153628
p_int:  0.999999721
p_ni:  2.79e-7
Data Source:  BioPlex
SAYSD1
Tdark
Novelty:  0.62764863
p_int:  0.999999329
p_ni:  6.71e-7
Data Source:  BioPlex
MBLAC2
Tdark
Family:  Enzyme
Novelty:  0.47407992
p_int:  0.999989836
p_ni:  0.000010164
Data Source:  BioPlex
LITAF
Tbio
Family:  TF
Novelty:  0.0097203
p_int:  0.999535551
p_ni:  0.000464449
Data Source:  BioPlex
TMEFF1
Tbio
Novelty:  0.11856207
p_int:  0.999215119
p_ni:  0.000784879
p_wrong:  2e-9
Score:  0.213
Data Source:  BioPlex,STRINGDB
MATN4
Tdark
Novelty:  0.31964843
p_int:  0.997601089
p_ni:  0.002398808
p_wrong:  1.04e-7
Data Source:  BioPlex
TMEM128
Tdark
Novelty:  5.15874803
p_int:  0.99414319
p_ni:  0.005856786
p_wrong:  2.3e-8
Data Source:  BioPlex
VCAM1
Tchem
Novelty:  0.00022504
p_int:  0.991876045
p_ni:  0.00812326
p_wrong:  6.95e-7
Score:  0.19
Data Source:  BioPlex,STRINGDB
ACYP2
Tbio
Family:  Enzyme
Novelty:  0.03063981
p_int:  0.989035304
p_ni:  0.010963567
p_wrong:  0.000001129
Data Source:  BioPlex
IMPDH1
Tclin
Family:  Enzyme
Novelty:  0.00758575
p_int:  0.985161789
p_ni:  0.014837926
p_wrong:  2.85e-7
Score:  0.247
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Mitochondrial protein import (R-HSA-1268020)

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Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Mitochondrial protein import
Protein localization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
2
2
91.4
hemoglobin measurement
2
2
2
88.4
reticulocyte count
1
1
1
75.1
body mass index
2
1
2
58.4
body height
1
2
2
49.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
91.4
hemoglobin measurement
2
88.4
reticulocyte count
1
75.1
body mass index
2
58.4
body height
2
49.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone
VGNC:103
459946
Mouse
MGI:1914071
66821
Rat
RGD:1359658
301514
Dog
BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone
VGNC:38421
478911
Horse
BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone
VGNC:15803
100055811
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone
Mouse
Rat
Dog
BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone
Horse
BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone
Publication Statistics
PubMed Score 65.78
PubMed score by year
PubTator Score 121.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title