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Tbio
BCORL1
BCL-6 corepressor-like protein 1

Protein Summary
Description
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. The protein encoded by this gene is a transcriptional corepressor that is found tethered to promoter regions by DNA-binding proteins. The encoded protein can interact with several different class II histone deacetylases to repress transcription. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000218147
  • ENSP00000218147
  • ENSG00000085185
  • ENST00000540052
  • ENSP00000437775

Symbol
  • BCoR-L1
  • CXorf10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.69
small molecule perturbation
0.69
kinase perturbation
0.6
disease perturbation
0.56
microRNA
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.51   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.51   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
PCGF6
Tbio
Novelty:  0.07032909
p_int:  0.999999845
p_ni:  1.55e-7
Score:  0.841
Data Source:  BioPlex,STRINGDB
PCGF2
Tbio
Novelty:  0.02148755
p_int:  0.99999931
p_ni:  6.9e-7
Score:  0.896
Data Source:  BioPlex,STRINGDB
RYBP
Tbio
Novelty:  0.01140945
p_int:  0.99996652
p_ni:  0.000033463
p_wrong:  1.7e-8
Score:  0.819
Data Source:  BioPlex,STRINGDB
YAF2
Tbio
Novelty:  0.10772286
p_int:  0.999943362
p_ni:  0.000056632
p_wrong:  6e-9
Score:  0.764
Data Source:  BioPlex,STRINGDB
CTBP1
Tbio
Novelty:  0.00243818
p_int:  0.999727666
p_ni:  0.000272334
Score:  0.635
Data Source:  BioPlex,STRINGDB
BAG4
Tbio
Novelty:  0.02660607
p_int:  0.998712074
p_ni:  0.000980801
p_wrong:  0.000307125
Score:  0.341
Data Source:  BioPlex,STRINGDB
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.996591001
p_ni:  0.003038102
p_wrong:  0.000370897
Score:  0.953
Data Source:  BioPlex,STRINGDB
FBL
Tbio
Family:  Enzyme
Novelty:  0.00080634
p_int:  0.895242021
p_ni:  0.005283373
p_wrong:  0.099474606
Data Source:  BioPlex
PCGF1
Tbio
Novelty:  0.06481661
Score:  0.979
Data Source:  STRINGDB
KDM2B
Tchem
Family:  Epigenetic
Novelty:  0.01630517
Score:  0.948
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Mesodermal Commitment Pathway
WikiPathways
Endoderm Differentiation
WikiPathways
Pathways Affected in Adenoid Cystic Carcinoma
Name
Explore in Pharos
Explore in Source
Mesodermal Commitment Pathway
Endoderm Differentiation
Pathways Affected in Adenoid Cystic Carcinoma
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
1
1
1
47.7
sex hormone-binding globulin measurement
4
1
4
43.8
mean platelet volume
1
1
1
32.6
neutrophil count
1
1
1
31.4
hematocrit
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
1
47.7
sex hormone-binding globulin measurement
4
43.8
mean platelet volume
1
32.6
neutrophil count
1
31.4
hematocrit
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
BCL6 corepressor like 1
702657
Mouse
MGI:2443910
320376
Rat
RGD:1566108
302810
Dog
BCL6 corepressor like 1
VGNC:38419
481047
Horse
BCL6 corepressor like 1
VGNC:15802
100054632
Species
Name
OMA
EggNOG
Inparanoid
Macaque
BCL6 corepressor like 1
Mouse
Rat
Dog
BCL6 corepressor like 1
Horse
BCL6 corepressor like 1
Publication Statistics
PubMed Score 30.51
PubMed score by year
PubTator Score 13.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title