Tbio BCOR BCL-6 corepressor

Protein Summary

Description

Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.[provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• Q6W2J9
• D3DWB3
• D3DWB4
• Q29RF6
• Q6P4B6
• Q7Z2K7
• Q8TEB4
• Q96DB3
• Q9H232
• Q9H233
• Q9HCJ7
• Q9NXF2
• BCoR

Gene Name

• BCOR

Ensembl ID

• ENST00000342274
• ENSP00000345923
• ENSG00000183337
• ENST00000378444
• ENSP00000367705
• ENST00000378455
• ENSP00000367716
• ENST00000397354
• ENSP00000380512

Symbol

• KIAA1575
• MAA2
• ANOP2
• MCOPS2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
biological process	0.9
virus perturbation	0.85
transcription factor binding site profile	0.82
transcription factor	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.13   (req: < 5)

Gene RIFs: 96   (req: <= 3)

Antibodies: 243   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.13   (req: >= 5)

Gene RIFs: 96   (req: > 3)

Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0