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Tbio
BCL9
B-cell CLL/lymphoma 9 protein

Protein Summary
Description
Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234739
  • ENSP00000234739
  • ENSG00000116128

Symbol
  • LGS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.71
small molecule perturbation
0.69
transcription factor
0.64
microRNA
0.63
cell line
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.26   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.26   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (94)
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.999
Data Source:  Reactome,STRINGDB
PYGO1
Tdark
Family:  Epigenetic
Novelty:  0.18099753
Score:  0.999
Data Source:  Reactome,STRINGDB
HIST3H3
Tbio
Novelty:  0.04915012
Score:  0.994
Data Source:  STRINGDB
PYGO2
Tbio
Family:  Epigenetic
Novelty:  0.04196406
Score:  0.986
Data Source:  Reactome,STRINGDB
H3F3C
Tbio
Novelty:  0.07135811
Score:  0.956
Data Source:  STRINGDB
H3F3A
Tbio
Novelty:  0.00508186
Score:  0.956
Data Source:  STRINGDB
LEF1
Tchem
Family:  TF
Novelty:  0.00168638
Score:  0.95
Data Source:  Reactome,STRINGDB
HIST2H3A
Tbio
Novelty:  0.02749981
Score:  0.949
Data Source:  STRINGDB
BTRC
Tbio
Novelty:  0.00293475
Score:  0.947
Data Source:  STRINGDB
HIST1H3A
Tbio
Novelty:  0.00991842
Score:  0.943
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Deactivation of the beta-catenin transactivating complex (R-HSA-3769402)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deactivation of the beta-catenin transactivating complex
Reactome
Formation of the beta-catenin:TCF transactivating complex
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
TCF dependent signaling in response to WNT
Name
Explore in Pharos
Explore in Source
Deactivation of the beta-catenin transactivating complex
Formation of the beta-catenin:TCF transactivating complex
Signal Transduction
Signaling by WNT
TCF dependent signaling in response to WNT
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
1
1
78.6
leukocyte count
1
1
1
78.3
granulocyte count
1
1
1
47.7
body height
1
1
1
21.5
triglyceride change measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
78.6
leukocyte count
1
78.3
granulocyte count
1
47.7
body height
1
21.5
triglyceride change measurement
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
B-cell CLL/lymphoma 9
700800
Mouse
MGI:1924828
77578
Rat
RGD:1306934
310704
Dog
B-cell CLL/lymphoma 9
483154
Horse
B-cell CLL/lymphoma 9
100065022
Species
Name
OMA
EggNOG
Inparanoid
Macaque
B-cell CLL/lymphoma 9
Mouse
Rat
Dog
B-cell CLL/lymphoma 9
Horse
B-cell CLL/lymphoma 9
Publication Statistics
PubMed Score 70.26
PubMed score by year
PubTator Score 39.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title