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Tdark
BCL7C
B-cell CLL/lymphoma 7 protein family member C

Protein Summary
Description
May play an anti-apoptotic role. This gene is identified by the similarity of its product to the N-terminal region of BCL7A protein. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. The function of this gene has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215115
  • ENSP00000215115
  • ENSG00000099385
  • ENST00000380317
  • ENSP00000369674
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.87
transcription factor perturbation
0.84
kinase
0.72
transcription factor binding site profile
0.71
hub protein
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.89   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.89   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
DPF3
Tbio
Family:  Epigenetic
Novelty:  0.069151
p_int:  0.999999993
p_ni:  7e-9
Score:  0.877
Data Source:  BioPlex,STRINGDB
PHACTR2
Tbio
Family:  Enzyme
Novelty:  0.25056698
p_int:  0.99999998
p_ni:  5e-9
p_wrong:  1.5e-8
Score:  0.558
Data Source:  BioPlex,STRINGDB
BRD7
Tchem
Family:  Epigenetic
Novelty:  0.01820848
p_int:  0.999999973
p_ni:  2.7e-8
Score:  0.861
Data Source:  BioPlex,STRINGDB
BRD9
Tchem
Family:  Epigenetic
Novelty:  0.03450227
p_int:  0.999999946
p_ni:  5.2e-8
p_wrong:  1e-9
Score:  0.839
Data Source:  BioPlex,STRINGDB
PHACTR4
Tbio
Family:  Enzyme
Novelty:  0.11366977
p_int:  0.999999931
p_ni:  6.6e-8
p_wrong:  3e-9
Data Source:  BioPlex
BICRA
Tbio
Novelty:  0.13482404
p_int:  0.999999914
p_ni:  8.6e-8
Score:  0.947
Data Source:  BioPlex,STRINGDB
SMARCC2
Tbio
Family:  TF; Epigenetic
Novelty:  0.02625321
p_int:  0.999999892
p_ni:  1.08e-7
Score:  0.89
Data Source:  BioPlex,STRINGDB
BICRAL
Tdark
Novelty:  1.34358936
p_int:  0.999999854
p_ni:  1.46e-7
Score:  0.741
Data Source:  BioPlex,STRINGDB
SMARCD1
Tbio
Novelty:  0.03176642
p_int:  0.999999848
p_ni:  1.52e-7
Score:  0.898
Data Source:  BioPlex,STRINGDB
INO80
Tbio
Family:  Enzyme
Novelty:  0.09412936
p_int:  0.999999285
p_ni:  7.15e-7
Score:  0.192
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.2
83.1
mean reticulocyte volume
1
1
1
82.8
mean corpuscular volume
1
1
1
82.2
serum non-albumin protein measurement
1
1
1
71.3
eosinophil count
1
1
1
62.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
83.1
mean reticulocyte volume
1
82.8
mean corpuscular volume
1
82.2
serum non-albumin protein measurement
1
71.3
eosinophil count
1
62.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BCL tumor suppressor 7C
VGNC:9385
467954
Macaque
BCL tumor suppressor 7C
712065
Mouse
MGI:1332237
12055
Rat
RGD:1308439
293514
Dog
BCL tumor suppressor 7C
VGNC:38414
479774
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BCL tumor suppressor 7C
Macaque
BCL tumor suppressor 7C
Mouse
Rat
Dog
BCL tumor suppressor 7C
Publication Statistics
PubMed Score 2.89
PubMed score by year
PubTator Score 1.51
PubTator score by year
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Related Publications
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PMID
Year
Title