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Tbio
BCL7B
B-cell CLL/lymphoma 7 protein family member B

Protein Summary
Description
Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (PubMed:25569233). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (PubMed:25569233). May play a role in lung tumor development or progression (By similarity). This gene encodes a member of the BCL7 family including BCL7A, BCL7B and BCL7C proteins. This member is BCL7B, which contains a region that is highly similar to the N-terminal segment of BCL7A or BCL7C proteins. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. This gene is located at a chromosomal region commonly deleted in Williams syndrome. This gene is highly conserved from C. elegans to human. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223368
  • ENSP00000223368
  • ENSG00000106635
  • ENST00000411832
  • ENSP00000393230
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
transcription factor binding site profile
0.75
transcription factor
0.73
histone modification site profile
0.72
disease perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.47   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.47   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
SMARCC2
Tbio
Family:  TF; Epigenetic
Novelty:  0.02625321
p_int:  0.999997599
p_ni:  0.000002401
Score:  0.875
Data Source:  BioPlex,STRINGDB
DPF2
Tbio
Family:  Epigenetic
Novelty:  0.0403366
p_int:  0.999994425
p_ni:  0.000004494
p_wrong:  0.000001081
Score:  0.909
Data Source:  BioPlex,STRINGDB
DPF3
Tbio
Family:  Epigenetic
Novelty:  0.069151
p_int:  0.999993581
p_ni:  0.000006419
Score:  0.913
Data Source:  BioPlex,STRINGDB
SMARCB1
Tbio
Novelty:  0.00116387
p_int:  0.99999224
p_ni:  0.00000776
Score:  0.928
Data Source:  BioPlex,STRINGDB
SMARCD1
Tbio
Novelty:  0.03176642
p_int:  0.999977277
p_ni:  0.000022565
p_wrong:  1.59e-7
Score:  0.904
Data Source:  BioPlex,STRINGDB
BCL7C
Tdark
Novelty:  0.31203802
p_int:  0.999966228
p_ni:  5e-9
p_wrong:  0.000033768
Score:  0.775
Data Source:  BioPlex,STRINGDB
SS18
Tbio
Novelty:  0.00915548
p_int:  0.999861472
p_ni:  0.000138278
p_wrong:  2.5e-7
Score:  0.938
Data Source:  BioPlex,STRINGDB
SMARCE1
Tbio
Family:  TF
Novelty:  0.01748089
p_int:  0.999734605
p_ni:  0.000265336
p_wrong:  6e-8
Score:  0.864
Data Source:  BioPlex,STRINGDB
NUP50
Tbio
Novelty:  0.03424725
p_int:  0.999593687
p_ni:  0.000323421
p_wrong:  0.000082892
Score:  0.524
Data Source:  BioPlex,STRINGDB
HDGFL2
Tbio
Family:  Epigenetic
Novelty:  0.11846257
p_int:  0.999346421
p_ni:  0.000643814
p_wrong:  0.000009765
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (59)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
27
26
57
9.4
99.9
serum gamma-glutamyl transferase measurement
5
7
6
4.5
99.1
high density lipoprotein cholesterol measurement
10
13
22
98.5
sleep duration
4
5
5
97.9
urate measurement
6
5
8
97.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
57
9.4
99.9
serum gamma-glutamyl transferase measurement
6
4.5
99.1
high density lipoprotein cholesterol measurement
22
98.5
sleep duration
5
97.9
urate measurement
8
97.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
BCL tumor suppressor 7B
716470
Mouse
MGI:1332238
12054
Rat
RGD:1597090
368001
Dog
BCL tumor suppressor 7B
VGNC:38413
489808
Cow
BCL tumor suppressor 7B
VGNC:26450
615062
Species
Name
OMA
EggNOG
Inparanoid
Macaque
BCL tumor suppressor 7B
Mouse
Rat
Dog
BCL tumor suppressor 7B
Cow
BCL tumor suppressor 7B
Publication Statistics
PubMed Score 9.47
PubMed score by year
PubTator Score 7.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title