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Tbio
BCL7A
B-cell CLL/lymphoma 7 protein family member A

Protein Summary
Description
This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261822
  • ENSP00000261822
  • ENSG00000110987
  • ENST00000538010
  • ENSP00000445868
  • ENST00000635191
  • ENSP00000489010
  • ENSG00000282873
  • ENST00000635403
  • ENSP00000489305

Symbol
  • BCL7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
virus perturbation
0.72
transcription factor perturbation
0.68
microRNA
0.65
transcription factor binding site profile
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.72   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.72   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (91)
POTEJ
Tdark
Novelty:  3.48973607
p_int:  0.999999998
p_wrong:  2e-9
Score:  0.23
Data Source:  BioPlex,STRINGDB
SPIRE1
Tbio
Novelty:  0.04929601
p_int:  0.999999977
p_ni:  1.3e-8
p_wrong:  1e-8
Score:  0.671
Data Source:  BioPlex,STRINGDB
PHACTR4
Tbio
Family:  Enzyme
Novelty:  0.11366977
p_int:  0.999999971
p_ni:  2.7e-8
p_wrong:  2e-9
Data Source:  BioPlex
SPIRE2
Tbio
Novelty:  0.06697946
p_int:  0.999999933
p_ni:  1.2e-8
p_wrong:  5.5e-8
Score:  0.189
Data Source:  BioPlex,STRINGDB
PHACTR2
Tbio
Family:  Enzyme
Novelty:  0.25056698
p_int:  0.999999889
p_ni:  1.1e-7
Score:  0.439
Data Source:  BioPlex,STRINGDB
BRD9
Tchem
Family:  Epigenetic
Novelty:  0.03450227
p_int:  0.999999866
p_ni:  1.32e-7
p_wrong:  3e-9
Score:  0.818
Data Source:  BioPlex,STRINGDB
MRTFB
Tbio
Novelty:  0.02702072
p_int:  0.999999614
p_ni:  3.52e-7
p_wrong:  3.5e-8
Score:  0.189
Data Source:  BioPlex,STRINGDB
DPF3
Tbio
Family:  Epigenetic
Novelty:  0.069151
p_int:  0.999999459
p_ni:  5.41e-7
Score:  0.899
Data Source:  BioPlex,STRINGDB
BICRA
Tbio
Novelty:  0.13482404
p_int:  0.999999079
p_ni:  9.2e-7
Score:  0.927
Data Source:  BioPlex,STRINGDB
SMARCC2
Tbio
Family:  TF; Epigenetic
Novelty:  0.02625321
p_int:  0.999999079
p_ni:  9.21e-7
Score:  0.907
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
7
3
7
97.9
urate measurement
5
4
5
90.8
BMI-adjusted waist-hip ratio
1
7
7
90.7
waist-hip ratio
1
7
7
90.4
BMI-adjusted hip circumference
2
8
9
86.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
7
97.9
urate measurement
5
90.8
BMI-adjusted waist-hip ratio
7
90.7
waist-hip ratio
7
90.4
BMI-adjusted hip circumference
9
86.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BCL tumor suppressor 7A
VGNC:12796
465189
Macaque
BCL tumor suppressor 7A
705028
Mouse
MGI:1924295
77045
Dog
BCL tumor suppressor 7A
VGNC:38412
486256
Horse
BCL tumor suppressor 7A
VGNC:15796
100059917
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BCL tumor suppressor 7A
Macaque
BCL tumor suppressor 7A
Mouse
Dog
BCL tumor suppressor 7A
Horse
BCL tumor suppressor 7A
Publication Statistics
PubMed Score 16.72
PubMed score by year
PubTator Score 8.95
PubTator score by year
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Related Publications
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PMID
Year
Title