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Tchem
BCL6
B-cell lymphoma 6 protein

Protein Summary
Description
Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiol ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000232014
  • ENSP00000232014
  • ENSG00000113916
  • ENST00000406870
  • ENSP00000384371
  • ENST00000450123
  • ENSP00000413122
  • ENST00000621333
  • ENSP00000479784

Symbol
  • BCL5
  • LAZ3
  • ZBTB27
  • ZNF51
  • BCL5
  • LAZ3
  • BCL6A
  • ZNF51
  • ZBTB27
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
gene perturbation
0.99
kinase perturbation
0.99
PubMedID
0.95
transcription factor
0.93


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1740.29   (req: < 5)
Gene RIFs: 256   (req: <= 3)
Antibodies: 835   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1740.29   (req: >= 5)
Gene RIFs: 256   (req: > 3)
Antibodies: 835   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 70
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0