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Tchem
BCL6
B-cell lymphoma 6 protein

Protein Summary
Description
Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiol ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000232014
  • ENSP00000232014
  • ENSG00000113916
  • ENST00000406870
  • ENSP00000384371
  • ENST00000450123
  • ENSP00000413122
  • ENST00000621333
  • ENSP00000479784

Symbol
  • BCL5
  • LAZ3
  • ZBTB27
  • ZNF51
  • BCL5
  • LAZ3
  • BCL6A
  • ZNF51
  • ZBTB27
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
gene perturbation
0.99
kinase perturbation
0.99
PubMedID
0.95
transcription factor
0.93


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1583.16   (req: < 5)
Gene RIFs: 256   (req: <= 3)
Antibodies: 835   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1583.16   (req: >= 5)
Gene RIFs: 256   (req: > 3)
Antibodies: 835   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 68
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (285)
NAXD
Tbio
Family:  Enzyme
Novelty:  0.07681941
p_int:  0.777512839
p_ni:  0.222448992
p_wrong:  0.000038169
Score:  0.369
Data Source:  BioPlex,STRINGDB
BCOR
Tbio
Novelty:  0.05718292
Score:  0.997
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.995
Data Source:  STRINGDB
IRF4
Tbio
Family:  TF
Novelty:  0.00192973
Score:  0.994
Data Source:  STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.981
Data Source:  STRINGDB
CD79A
Tbio
Novelty:  0.00118942
Score:  0.978
Data Source:  STRINGDB
CD19
Tclin
Novelty:  0.0001816
Score:  0.966
Data Source:  STRINGDB
PTPRC
Tchem
Family:  Enzyme
Novelty:  0.00012027
Score:  0.963
Data Source:  STRINGDB
STAT6
Tchem
Family:  TF
Novelty:  0.00096732
Score:  0.955
Data Source:  STRINGDB
CD22
Tclin
Novelty:  0.0009372
Score:  0.954
Data Source:  STRINGDB
Pathways (26)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FOXO-mediated transcription
Reactome
FOXO-mediated transcription of cell death genes
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FOXO-mediated transcription
FOXO-mediated transcription of cell death genes
Gene expression (Transcription)
Generic Transcription Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (52)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil percentage of leukocytes
2
2
2
79.3
body height
1
1
1
66
basophil count
2
2
2
65.9
monocyte percentage of leukocytes
1
1
1
64
basophil percentage of granulocytes
1
1
1
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil percentage of leukocytes
2
79.3
body height
1
66
basophil count
2
65.9
monocyte percentage of leukocytes
1
64
basophil percentage of granulocytes
1
53.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
B cell CLL/lymphoma 6
VGNC:9935
460926
Macaque
B-cell CLL/lymphoma 6
708736
Mouse
MGI:107187
12053
Rat
RGD:1309345
303836
Dog
B-cell lymphoma 6 protein [Source:RefSeq peptide;Acc:NP_001182333]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
B cell CLL/lymphoma 6
Macaque
B-cell CLL/lymphoma 6
Mouse
Rat
Dog
B-cell lymphoma 6 protein [Source:RefSeq peptide;Acc:NP_001182333]
Publication Statistics
PubMed Score 1583.16
PubMed score by year
PubTator Score 923.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title