Protein Summary
Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]
- ENST00000250405
- ENSP00000250405
- ENSG00000129473
- ENST00000553781
- ENSP00000451320
- ENSG00000258643
- ENST00000557008
- ENSP00000452479
- BCLW
- KIAA0271
- BCLW
- BCL-W
- PPP1R51
- BCL2-L-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
disease perturbation | 0.87 | ||
microRNA | 0.74 | ||
transcription factor perturbation | 0.74 | ||
cellular component | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 185.53 (req: < 5)
Gene RIFs: 43 (req: <= 3)
Antibodies: 390 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 185.53 (req: >= 5)
Gene RIFs: 43 (req: > 3)
Antibodies: 390 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 17
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (17)
Protein-Protein Interactions (79)
Q9BXH1
Novelty: 0.00773944
p_int: 0.999999959
p_ni: 4e-8
Score: 0.833
Data Source: BioPlex,STRINGDB
BAX
Novelty: 0.00150653
p_int: 0.999995545
p_ni: 0.000004455
Score: 0.749
Data Source: BioPlex,STRINGDB
BID
Novelty: 0.01264688
p_int: 0.998423938
p_ni: 0.001576056
p_wrong: 6e-9
Score: 0.963
Data Source: BioPlex,STRINGDB
BCL2L11
Novelty: 0.00055914
p_int: 0.99703184
p_ni: 0.00296815
p_wrong: 1e-8
Score: 0.982
Data Source: BioPlex,STRINGDB
SLC27A2
Family: Transporter
Novelty: 0.01436035
p_int: 0.984597891
p_ni: 0.015402109
Score: 0.18
Data Source: BioPlex,STRINGDB
NKAPD1
Novelty: 1.56979675
p_int: 0.902339223
p_ni: 0.000101029
p_wrong: 0.097559748
Data Source: BioPlex
Nearest Tclin Targets
Pathways (90)
KEGG (1)
PathwayCommons (2)
WikiPathways (87)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | MicroRNAs in cancer | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
MicroRNAs in cancer | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (5)
Components (3)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (48)
Items per page:
1 – 5 of 48
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 6 | 3 | 6 | 95.1 | ||||||
sex hormone-binding globulin measurement | 6 | 3 | 6 | 95.1 | ||||||
BMI-adjusted hip circumference | 2 | 7 | 8 | 87.7 | ||||||
BMI-adjusted hip circumference | 2 | 7 | 8 | 87.7 | ||||||
electrocardiography | 2 | 1 | 61 | 5.3 | 83.4 | |||||
Items per page:
1 – 5 of 48
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 6 | 95.1 | |||||
sex hormone-binding globulin measurement | 6 | 95.1 | |||||
BMI-adjusted hip circumference | 8 | 87.7 | |||||
BMI-adjusted hip circumference | 8 | 87.7 | |||||
electrocardiography | 61 | 5.3 | 83.4 | ||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | BCL2 like 2 | VGNC:12984 | 100611631 | |||||
Mouse | MGI:108052 | 12050 | ||||||
Rat | RGD:620717 | 60434 | ||||||
Dog | BCL2 like 2 | 490611 | ||||||
Horse | BCL2 like 2 | VGNC:50577 | 100055644 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | BCL2 like 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | BCL2 like 2 | |||||
Horse | BCL2 like 2 | |||||
Publication Statistics
PubMed Score 185.53
PubMed score by year
PubTator Score 111.19
PubTator score by year
Related Publications
Text Mined References (90)
GeneRif Annotations (43)
Items per page:
0 of 0
PMID | Year | Title |
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