Protein Summary
Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis. The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene i ...more
- ENST00000308659
- ENSP00000309226
- ENSG00000153094
- ENST00000337565
- ENSP00000338374
- ENST00000393256
- ENSP00000376943
- ENST00000405953
- ENSP00000384641
- ENST00000415458
- ENSP00000393781
- ENST00000431217
- ENSP00000394640
- ENST00000433098
- ENSP00000401662
- ENST00000436733
- ENSP00000403727
- ENST00000437029
- ENSP00000412892
- ENST00000439718
- ENSP00000411137
- ENST00000452231
- ENSP00000391292
- ENST00000610735
- ENSP00000481030
- ENST00000615946
- ENSP00000481423
- ENST00000619294
- ENSP00000479714
- ENST00000620862
- ENSP00000478133
- ENST00000621302
- ENSP00000481652
- ENST00000622509
- ENSP00000482175
- ENST00000622612
- ENSP00000484360
- ENST00000639340
- ENSP00000491154
- ENST00000640419
- ENSP00000491422
- BIM
- BAM
- BIM
- BOD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
microRNA | 1 | ||
transcription factor perturbation | 0.99 | ||
kinase | 0.98 | ||
biological term | 0.96 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1848.96 (req: < 5)
Gene RIFs: 347 (req: <= 3)
Antibodies: 1169 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1848.96 (req: >= 5)
Gene RIFs: 347 (req: > 3)
Antibodies: 1169 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 46
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (3)
Protein-Protein Interactions (308)
BCL2L1
Novelty: 0.00018414
p_int: 0.999999936
p_ni: 6.4e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
RHPN2
Novelty: 0.04808006
p_int: 0.999998126
p_ni: 9e-9
p_wrong: 0.000001865
Score: 0.224
Data Source: BioPlex,STRINGDB
MTHFR
Family: Enzyme
Novelty: 0.00018162
p_int: 0.999353861
p_ni: 0.000646139
Data Source: BioPlex
ZAR1L
Novelty: 0.08793345
p_int: 0.998765064
p_ni: 0.001234818
p_wrong: 1.19e-7
Data Source: BioPlex
ANKLE2
Novelty: 0.0995907
p_int: 0.998379525
p_ni: 0.001620463
p_wrong: 1.2e-8
Score: 0.186
Data Source: BioPlex,STRINGDB
BCL2
Novelty: 0.00608635
p_int: 0.997509561
p_ni: 0.0006702
p_wrong: 0.001820241
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
BCL2L2
Novelty: 0.00430896
p_int: 0.99703184
p_ni: 0.00296815
p_wrong: 1e-8
Score: 0.982
Data Source: BioPlex,STRINGDB
EDNRA
Family: GPCR
Novelty: 0.00045591
p_int: 0.994878599
p_ni: 0.005121396
p_wrong: 5e-9
Score: 0.553
Data Source: BioPlex,STRINGDB
BTRC
Novelty: 0.00293475
p_int: 0.991882568
p_ni: 0.008117396
p_wrong: 3.6e-8
Score: 0.547
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (3)
Upstream (3)
1 – 3 of 3
Pathways (135)
Reactome (24)
KEGG (10)
PathwayCommons (7)
WikiPathways (94)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation of BH3-only proteins | ||||
Reactome | Activation of BIM and translocation to mitochondria | ||||
Reactome | Apoptosis | ||||
Reactome | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | ||||
Reactome | Cell death signalling via NRAGE, NRIF and NADE | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation of BH3-only proteins | ||||
Activation of BIM and translocation to mitochondria | ||||
Apoptosis | ||||
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | ||||
Cell death signalling via NRAGE, NRIF and NADE | ||||
Viral Interactions (0)
Gene Ontology Terms (54)
Functions (3)
Components (8)
Processes (43)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (47)
Items per page:
1 – 5 of 47
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 2 | 5 | 7 | 95.7 | |||||
testosterone measurement | 5 | 2 | 5 | 95 | |||||
eosinophil percentage of leukocytes | 2 | 2 | 2 | 94.5 | |||||
eosinophil count | 3 | 2 | 3 | 94.5 | |||||
6 | 4 | 0 | 1.4 | 93 | |||||
Items per page:
1 – 5 of 47
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 7 | 95.7 | |||||
testosterone measurement | 5 | 95 | |||||
eosinophil percentage of leukocytes | 2 | 94.5 | |||||
eosinophil count | 3 | 94.5 | |||||
0 | 1.4 | 93 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | BCL2 like 11 [Source:HGNC Symbol;Acc:HGNC:994] | |||||||
Mouse | MGI:1197519 | 12125 | ||||||
Rat | RGD:628774 | 64547 | ||||||
Dog | BCL2 like 11 | 612867 | ||||||
Horse | BCL2 like 11 | VGNC:49534 | 100064312 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | BCL2 like 11 [Source:HGNC Symbol;Acc:HGNC:994] | |||||
Mouse | ||||||
Rat | ||||||
Dog | BCL2 like 11 | |||||
Horse | BCL2 like 11 | |||||
Publication Statistics
PubMed Score 1848.96
PubMed score by year
PubTator Score 327.44
PubTator score by year
Related Publications
Text Mined References (413)
GeneRif Annotations (347)
Items per page:
0 of 0
PMID | Year | Title |
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