Tchem BCL2L11 Bcl-2-like protein 11

Protein Summary

Description

Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis. The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]

Uniprot Accession IDs

• O43521
• A8K2W2
• O43522
• Q0MSE7
• Q0MSE8
• Q0MSE9
• Q53R28
• Q6JTU6
• Q6T851
• Q6TE14
• Q6TE15
• Q6TE16
• Q6V402
• Q8WYL6
• Q8WYL7
• Q8WYL8
• Q8WYL9
• Q8WYM0
• Q8WYM1
• Bcl2-L-11

Gene Name

• BCL2L11

Ensembl ID

• ENST00000308659
• ENSP00000309226
• ENSG00000153094
• ENST00000337565
• ENSP00000338374
• ENST00000393256
• ENSP00000376943
• ENST00000405953
• ENSP00000384641
• ENST00000415458
• ENSP00000393781
• ENST00000431217
• ENSP00000394640
• ENST00000433098
• ENSP00000401662
• ENST00000436733
• ENSP00000403727
• ENST00000437029
• ENSP00000412892
• ENST00000439718
• ENSP00000411137
• ENST00000452231
• ENSP00000391292
• ENST00000610735
• ENSP00000481030
• ENST00000615946
• ENSP00000481423
• ENST00000619294
• ENSP00000479714
• ENST00000620862
• ENSP00000478133
• ENST00000621302
• ENSP00000481652
• ENST00000622509
• ENSP00000482175
• ENST00000622612
• ENSP00000484360
• ENST00000639340
• ENSP00000491154
• ENST00000640419
• ENSP00000491422

Symbol

• BIM
• BAM
• BIM
• BOD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
microRNA	1
transcription factor perturbation	0.99
kinase	0.98
biological term	0.96

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2054.02   (req: < 5)

Gene RIFs: 393   (req: <= 3)

Antibodies: 1169   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2054.02   (req: >= 5)

Gene RIFs: 393   (req: > 3)

Antibodies: 1169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0