Tchem BCL2L11 Bcl-2-like protein 11

Protein Summary

Description

Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis. The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]

Uniprot Accession IDs

• O43521
• A8K2W2
• O43522
• Q0MSE7
• Q0MSE8
• Q0MSE9
• Q53R28
• Q6JTU6
• Q6T851
• Q6TE14
• Q6TE15
• Q6TE16
• Q6V402
• Q8WYL6
• Q8WYL7
• Q8WYL8
• Q8WYL9
• Q8WYM0
• Q8WYM1
• Bcl2-L-11

Gene Name

• BCL2L11

Ensembl ID

• ENST00000308659
• ENSP00000309226
• ENSG00000153094
• ENST00000337565
• ENSP00000338374
• ENST00000393256
• ENSP00000376943
• ENST00000405953
• ENSP00000384641
• ENST00000415458
• ENSP00000393781
• ENST00000431217
• ENSP00000394640
• ENST00000433098
• ENSP00000401662
• ENST00000436733
• ENSP00000403727
• ENST00000437029
• ENSP00000412892
• ENST00000439718
• ENSP00000411137
• ENST00000452231
• ENSP00000391292
• ENST00000610735
• ENSP00000481030
• ENST00000615946
• ENSP00000481423
• ENST00000619294
• ENSP00000479714
• ENST00000620862
• ENSP00000478133
• ENST00000621302
• ENSP00000481652
• ENST00000622509
• ENSP00000482175
• ENST00000622612
• ENSP00000484360
• ENST00000639340
• ENSP00000491154
• ENST00000640419
• ENSP00000491422

Symbol

• BIM
• BAM
• BIM
• BOD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
microRNA	1
transcription factor perturbation	0.99
kinase	0.98
biological term	0.96

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1848.96   (req: < 5)

Gene RIFs: 347   (req: <= 3)

Antibodies: 1169   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1848.96   (req: >= 5)

Gene RIFs: 347   (req: > 3)

Antibodies: 1169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (3)

Explore Active Ligands

1 – 3 of 3

SID124756688

BCL2L11Tchem

pIC50 : 6.1

SID143472918

BCL2L11Tchem

pIC50 : 6.01

SID143472914

BCL2L11Tchem

pIC50 : 6

Protein-Protein Interactions (308)

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1 – 10 of 308

• See Interactions on String-DB

MCL1

Tchem

Novelty:  0.00046181

p_int:  1

Score:  0.998

Data Source:  BioPlex,STRINGDB

BCL2L1

Tchem

Novelty:  0.00018414

p_int:  0.999999936

p_ni:  6.4e-8

Score:  0.999

Data Source:  BioPlex,STRINGDB

RHPN2

Tbio

Novelty:  0.04808006

p_int:  0.999998126

p_ni:  9e-9

p_wrong:  0.000001865

Score:  0.224

Data Source:  BioPlex,STRINGDB

MTHFR

Tbio

Family:  Enzyme

Novelty:  0.00018162

p_int:  0.999353861

p_ni:  0.000646139

Data Source:  BioPlex

ZAR1L

Tdark

Novelty:  0.08793345

p_int:  0.998765064

p_ni:  0.001234818

p_wrong:  1.19e-7

Data Source:  BioPlex

ANKLE2

Tbio

Novelty:  0.0995907

p_int:  0.998379525

p_ni:  0.001620463

p_wrong:  1.2e-8

Score:  0.186

Data Source:  BioPlex,STRINGDB

BCL2

Tclin

Novelty:  0.00608635

p_int:  0.997509561

p_ni:  0.0006702

p_wrong:  0.001820241

Score:  0.997

Data Source:  BioPlex,Reactome,STRINGDB

BCL2L2

Tchem

Novelty:  0.00430896

p_int:  0.99703184

p_ni:  0.00296815

p_wrong:  1e-8

Score:  0.982

Data Source:  BioPlex,STRINGDB

EDNRA

Tclin

Family:  GPCR

Novelty:  0.00045591

p_int:  0.994878599

p_ni:  0.005121396

p_wrong:  5e-9

Score:  0.553

Data Source:  BioPlex,STRINGDB

BTRC

Tbio

Novelty:  0.00293475

p_int:  0.991882568

p_ni:  0.008117396

p_wrong:  3.6e-8

Score:  0.547

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets (3)

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Upstream (3)

1 – 3 of 3

MAP2K2

Tclin

Family:  Kinase

KEGG Distance:  3

Common Pathways:  7

1: PI3K-Akt signaling pathway

2: EGFR tyrosine kinase inhibitor resistance

3: FoxO signaling pathway

4: MicroRNAs in cancer

more:  3 more common pathways

IL6

Tclin

Family:  Other

KEGG Distance:  3

Common Pathways:  6

1: PI3K-Akt signaling pathway

2: EGFR tyrosine kinase inhibitor resistance

3: Non-alcoholic fatty liver disease (NAFLD)

4: FoxO signaling pathway

more:  2 more common pathways

MAP2K1

Tclin

Family:  Kinase

KEGG Distance:  3

Common Pathways:  7

1: PI3K-Akt signaling pathway

2: EGFR tyrosine kinase inhibitor resistance

3: FoxO signaling pathway

4: MicroRNAs in cancer

more:  3 more common pathways

Pathways (135)

Reactome (24)

KEGG (10)

PathwayCommons (7)

WikiPathways (94)

Activation of BH3-only proteins (R-HSA-114452)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of BH3-only proteins	31 targets	R-HSA-114452
Reactome	Activation of BIM and translocation to mitochondria	3 targets	R-HSA-111446
Reactome	Apoptosis	177 targets	R-HSA-109581
Reactome	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	10 targets	R-HSA-111453
Reactome	Cell death signalling via NRAGE, NRIF and NADE	76 targets	R-HSA-204998

Name	Explore in Pharos	Explore in Source
Activation of BH3-only proteins	31 targets	R-HSA-114452
Activation of BIM and translocation to mitochondria	3 targets	R-HSA-111446
Apoptosis	177 targets	R-HSA-109581
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	10 targets	R-HSA-111453
Cell death signalling via NRAGE, NRIF and NADE	76 targets	R-HSA-204998

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (54)

Functions (3)

Components (8)

Processes (43)

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1 – 3 of 3

GO Term	Evidence	Assigned by
microtubule binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protein heterodimerization activity	Inferred from Electronic Annotation (IEA)	Ensembl
protein kinase binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (47)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte percentage of leukocytes	EFO_0007989	2	5	7		95.7
testosterone measurement	EFO_0004908	5	2	5		95
eosinophil percentage of leukocytes	EFO_0007991	2	2	2		94.5
eosinophil count	EFO_0004842	3	2	3		94.5
chronic lymphocytic leukemia	EFO_0000095	6	4	0	1.4	93

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte percentage of leukocytes	EFO_0007989	7		95.7
testosterone measurement	EFO_0004908	5		95
eosinophil percentage of leukocytes	EFO_0007991	2		94.5
eosinophil count	EFO_0004842	3		94.5
chronic lymphocytic leukemia	EFO_0000095	0	1.4	93

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Apoptosis
Complete proteome
Membrane
Mitochondrion
Phosphoprotein
Reference proteome
Ubl conjugation

GWAS Trait Find Similar Targets

No Header	No Header
blood protein measurement
BMI-adjusted hip circumference
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
breast carcinoma
C-X-C motif chemokine 16 measurement
chronic lymphocytic leukemia
Churg-Strauss syndrome
eosinophil count
eosinophil percentage of granulocytes

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
cellular phenotype
endocrine/exocrine gland phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
mortality/aging
nervous system phenotype
renal/urinary system phenotype

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	BCL2 like 11 [Source:HGNC Symbol;Acc:HGNC:994]
Mouse	BCL2-like 11 (apoptosis facilitator)	MGI:1197519	12125
Rat	BCL2 like 11	RGD:628774	64547
Dog	BCL2 like 11		612867
Horse	BCL2 like 11	VGNC:49534	100064312

Species	Name	OMA	EggNOG	Inparanoid
Macaque	BCL2 like 11 [Source:HGNC Symbol;Acc:HGNC:994]
Mouse	BCL2-like 11 (apoptosis facilitator)
Rat	BCL2 like 11
Dog	BCL2 like 11
Horse	BCL2 like 11

Publication Statistics

PubMed Score 1848.96

PubMed score by year

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PubTator Score 327.44

PubTator score by year

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Related Publications

Text Mined References (413)

GeneRif Annotations (347)

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PMID	Year	Title