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Tchem
BCL2L1
Bcl-2-like protein 1

Protein Summary
Description
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). Isoform Bcl-X(S) promotes ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307677
  • ENSP00000302564
  • ENSG00000171552
  • ENST00000376055
  • ENSP00000365223
  • ENST00000376062
  • ENSP00000365230

Symbol
  • BCL2L
  • BCLX
  • BCLX
  • BCL2L
  • Bcl-X
  • PPP1R52
  • BCL-XL/S
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
transcription factor perturbation
1
biological process
0.99
kinase perturbation
0.99
protein domain
0.99


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4313.36   (req: < 5)
Gene RIFs: 461   (req: <= 3)
Antibodies: 1812   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4313.36   (req: >= 5)
Gene RIFs: 461   (req: > 3)
Antibodies: 1812   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 781
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (463)
BCL2L11
Tchem
Novelty:  0.00055914
p_int:  0.999999936
p_ni:  6.4e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
BAD
Tchem
Novelty:  0.01273317
p_int:  0.999998823
p_ni:  0.000001176
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
ZAR1L
Tdark
Novelty:  0.08793345
p_int:  0.999872652
p_ni:  0.00000567
p_wrong:  0.000121677
Data Source:  BioPlex
PDS5A
Tbio
Novelty:  0.0142948
p_int:  0.99967043
p_ni:  0.00032957
Score:  0.196
Data Source:  BioPlex,STRINGDB
BAX
Tchem
Novelty:  0.00150653
p_int:  0.996556649
p_ni:  0.003443351
Score:  0.998
Data Source:  BioPlex,STRINGDB
BCL2
Tclin
Novelty:  0.00608635
p_int:  0.875098823
p_ni:  8.3e-8
p_wrong:  0.124901094
Score:  0.991
Data Source:  BioPlex,STRINGDB
BID
Tbio
Novelty:  0.01264688
Score:  0.999
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.999
Data Source:  STRINGDB
CASP8
Tchem
Family:  Enzyme
Novelty:  0.00024321
Score:  0.999
Data Source:  STRINGDB
BECN1
Tbio
Novelty:  0.0003792
Score:  0.999
Data Source:  STRINGDB
Pathways (130)
Apoptosis (R-HSA-109581)

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Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Inflammasomes
Name
Explore in Pharos
Explore in Source
Apoptosis
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Cytokine Signaling in Immune system
Immune System
Inflammasomes
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (61)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
putamen volume
2
2
0
8.7
93.4
eosinophil count
4
3
4
85
mosaic loss of chromosome Y measurement
1
1
1
82.4
brain volume measurement
1
1
0
33.6
78.9
caudate nucleus volume
1
2
0
6.8
78.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
putamen volume
0
8.7
93.4
eosinophil count
4
85
mosaic loss of chromosome Y measurement
1
82.4
brain volume measurement
0
33.6
78.9
caudate nucleus volume
0
6.8
78.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BCL2 like 1
VGNC:9824
458156
Macaque
BCL2 like 1
713035
Mouse
MGI:88139
12048
Rat
RGD:2200
24888
Dog
BCL2 like 1
VGNC:38408
403618
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BCL2 like 1
Macaque
BCL2 like 1
Mouse
Rat
Dog
BCL2 like 1
Publication Statistics
PubMed Score 4313.36
PubMed score by year
PubTator Score 2903.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title