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Tclin
BCL2
Apoptosis regulator Bcl-2

Protein Summary
Description
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333681
  • ENSP00000329623
  • ENSG00000171791
  • ENST00000398117
  • ENSP00000381185
  • ENST00000589955
  • ENSP00000466417

Symbol
  • Bcl-2
  • PPP1R50
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
co-expressed gene
0.99
hub protein
0.99


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.13   (req: < 5)
Gene RIFs: 1535   (req: <= 3)
Antibodies: 3436   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.13   (req: >= 5)
Gene RIFs: 1535   (req: > 3)
Antibodies: 3436   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 122
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1476
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (200)
ABCB1
Tchem
Family:  Transporter
Novelty:  0.00018144
p_int:  0.999999915
p_ni:  6.7e-8
p_wrong:  1.8e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
Q96PG8
Tbio
Novelty:  0.00773944
p_int:  0.99999849
p_ni:  0.000001509
p_wrong:  1e-9
Score:  0.972
Data Source:  BioPlex,STRINGDB
BAD
Tchem
Novelty:  0.01273317
p_int:  0.999995706
p_ni:  0.000004294
Score:  0.994
Data Source:  BioPlex,Reactome,STRINGDB
MTHFR
Tbio
Family:  Enzyme
Novelty:  0.00018162
p_int:  0.999881692
p_ni:  0.000118308
p_wrong:  1e-9
Data Source:  BioPlex
BAX
Tchem
Novelty:  0.00150653
p_int:  0.999881038
p_ni:  0.000118962
Score:  0.967
Data Source:  BioPlex,STRINGDB
BCL2L11
Tchem
Novelty:  0.00055914
p_int:  0.997509561
p_ni:  0.0006702
p_wrong:  0.001820241
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
BCL2L1
Tchem
Novelty:  0.00018414
p_int:  0.875098823
p_ni:  8.3e-8
p_wrong:  0.124901094
Score:  0.991
Data Source:  BioPlex,STRINGDB
CASP8
Tchem
Family:  Enzyme
Novelty:  0.00024321
Score:  0.996
Data Source:  STRINGDB
CASP2
Tchem
Family:  Enzyme
Novelty:  0.00189892
Score:  0.995
Data Source:  STRINGDB
BID
Tbio
Novelty:  0.01264688
Score:  0.99
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (115)
Activation of BAD and translocation to mitochondria (R-HSA-111447)

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Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of BAD and translocation to mitochondria
Reactome
Activation of BH3-only proteins
Reactome
Apoptosis
Reactome
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Activation of BAD and translocation to mitochondria
Activation of BH3-only proteins
Apoptosis
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Cytokine Signaling in Immune system
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (135)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (60)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
5
97.2
eosinophil percentage of leukocytes
2
3
4
96.8
platelet crit
2
2
3
94.5
sex hormone-binding globulin measurement
5
3
10
93.2
serum non-albumin protein measurement
2
4
4
92.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
5
97.2
eosinophil percentage of leukocytes
4
96.8
platelet crit
3
94.5
sex hormone-binding globulin measurement
10
93.2
serum non-albumin protein measurement
4
92.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:88138
12043
Rat
RGD:2199
24224
Dog
BCL2, apoptosis regulator
VGNC:54274
403416
Horse
BCL2, apoptosis regulator
VGNC:15790
100050934
Cow
BCL2, apoptosis regulator
VGNC:26445
281020
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
BCL2, apoptosis regulator
Horse
BCL2, apoptosis regulator
Cow
BCL2, apoptosis regulator
Publication Statistics
PubMed Score 113.13
PubMed score by year
PubTator Score 14950.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title