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Tbio
BCL11A
B-cell lymphoma/leukemia 11A

Protein Summary
Description
Transcription factor associated with the BAF SWI/SNF chromatin remodeling complex (By similarity). Repressor of fetal hemoglobin (HbF) level (PubMed:26375765). Involved in brain development (PubMed:27453576). Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. Essential factor in lymphopoiesis required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1 (By similarity). This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335712
  • ENSP00000338774
  • ENSG00000119866
  • ENST00000356842
  • ENSP00000349300
  • ENST00000359629
  • ENSP00000352648
  • ENST00000409351
  • ENSP00000487844
  • ENST00000642384
  • ENSP00000496168

Symbol
  • CTIP1
  • EVI9
  • KIAA1809
  • ZNF856
  • EVI9
  • CTIP1
  • DILOS
  • ZNF856
  • HBFQTL5
  • BCL11A-L
  • BCL11A-S
  • BCL11a-M
  • BCL11A-XL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
transcription factor perturbation
1
molecular function
0.91
microRNA
0.86
transcription factor binding site profile
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 320.68   (req: < 5)
Gene RIFs: 93   (req: <= 3)
Antibodies: 417   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 320.68   (req: >= 5)
Gene RIFs: 93   (req: > 3)
Antibodies: 417   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (108)
UBXN4
Tbio
Novelty:  0.16206743
p_int:  0.999999994
p_ni:  5e-9
Score:  0.817
Data Source:  BioPlex,STRINGDB
MTA1
Tbio
Family:  TF
Novelty:  0.00464618
p_int:  0.999999568
p_ni:  4.32e-7
Score:  0.884
Data Source:  BioPlex,STRINGDB
MBD3L1
Tbio
Novelty:  0.11297566
p_int:  0.999999202
p_ni:  7.98e-7
Score:  0.834
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999985223
p_ni:  0.000014776
p_wrong:  1e-9
Score:  0.738
Data Source:  BioPlex,STRINGDB
PHF20L1
Tbio
Family:  Epigenetic
Novelty:  0.23101523
p_int:  0.99997854
p_ni:  0.00002146
Score:  0.829
Data Source:  BioPlex,STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
p_int:  0.999953537
p_ni:  0.000046463
Score:  0.924
Data Source:  BioPlex,STRINGDB
FGFR2
Tclin
Family:  Kinase
Novelty:  0.00066613
p_int:  0.99981838
p_ni:  0.000181102
p_wrong:  5.18e-7
Score:  0.27
Data Source:  BioPlex,STRINGDB
NR2F2
Tchem
Family:  NR
Novelty:  0.00450561
Score:  0.881
Data Source:  STRINGDB
HBG2
Tbio
Novelty:  0.01145628
Score:  0.808
Data Source:  STRINGDB
HBG1
Tbio
Novelty:  0.00384136
Score:  0.808
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (49)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
6
4
3
1.1
98.8
self reported educational attainment
6
7
6
4.2
98.7
mean corpuscular volume
2
4
4
96.3
fetal hemoglobin measurement
2
1
1
13.1
95.4
educational attainment
2
6
5
56.9
94.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
3
1.1
98.8
self reported educational attainment
6
4.2
98.7
mean corpuscular volume
4
96.3
fetal hemoglobin measurement
1
13.1
95.4
educational attainment
5
56.9
94.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
B cell CLL/lymphoma 11A
VGNC:3831
742644
Mouse
MGI:106190
14025
Rat
RGD:1309923
305589
Dog
B-cell CLL/lymphoma 11A
481381
Pig
B-cell CLL/lymphoma 11A
100523730
Species
Name
OMA
EggNOG
Inparanoid
Chimp
B cell CLL/lymphoma 11A
Mouse
Rat
Dog
B-cell CLL/lymphoma 11A
Pig
B-cell CLL/lymphoma 11A
Publication Statistics
PubMed Score 320.68
PubMed score by year
PubTator Score 173.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title