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Tchem
BCAT2
Branched-chain-amino-acid aminotransferase, mitochondrial

Protein Summary
Description
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids. This gene encodes a branched chain aminotransferase found in mitochondria. The encoded protein forms a dimer that catalyzes the first step in the production of the branched chain amino acids leucine, isoleucine, and valine. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316273
  • ENSP00000322991
  • ENSG00000105552
  • ENST00000545387
  • ENSP00000440973

Symbol
  • BCATM
  • BCT2
  • ECA40
  • BCAM
  • BCT2
  • PP18
  • BCATM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
histone modification site profile
0.84
transcription factor
0.77
PubMedID
0.76
co-expressed gene
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.78   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.78   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 47
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (47)
CHEMBL3617085
Rendered image for CHEMBL3617085
CHEMBL3617078
Rendered image for CHEMBL3617078
CHEMBL3794222
Rendered image for CHEMBL3794222
compound 42 [PMID: 26938474]
Rendered image for compound 42 [PMID: 26938474]
CHEMBL3617086
Rendered image for CHEMBL3617086
CHEMBL3617084
Rendered image for CHEMBL3617084
CHEMBL3617083
Rendered image for CHEMBL3617083
CHEMBL3617082
Rendered image for CHEMBL3617082
CHEMBL3617080
Rendered image for CHEMBL3617080
CHEMBL3617095
Rendered image for CHEMBL3617095
Protein-Protein Interactions (95)
YBEY
Tdark
Family:  Enzyme
Novelty:  0.02778029
p_int:  0.999931925
p_ni:  0.000066971
p_wrong:  0.000001104
Score:  0.348
Data Source:  BioPlex,STRINGDB
EEF2KMT
Tdark
Family:  Enzyme
Novelty:  0.33892681
p_int:  0.999885879
p_ni:  0.000114118
p_wrong:  3e-9
Score:  0.548
Data Source:  BioPlex,STRINGDB
NDUFS6
Tclin
Family:  Enzyme
Novelty:  0.07910252
p_int:  0.995429847
p_ni:  0.004568907
p_wrong:  0.000001246
Score:  0.205
Data Source:  BioPlex,STRINGDB
HSPD1
Tbio
Novelty:  0.00018924
p_int:  0.992040477
p_ni:  0.007959523
Score:  0.25
Data Source:  BioPlex,STRINGDB
NIT1
Tbio
Family:  Enzyme
Novelty:  0.00498587
p_int:  0.788540861
p_ni:  0.211458831
p_wrong:  3.08e-7
Score:  0.242
Data Source:  BioPlex,STRINGDB
BCKDHB
Tbio
Family:  Enzyme
Novelty:  0.02234969
Score:  0.972
Data Source:  STRINGDB
BCKDHA
Tbio
Family:  Enzyme
Novelty:  0.01684893
Score:  0.966
Data Source:  STRINGDB
DBT
Tbio
Family:  Enzyme
Novelty:  0.0070589
Score:  0.963
Data Source:  STRINGDB
DLD
Tbio
Family:  Enzyme
Novelty:  0.00214298
Score:  0.955
Data Source:  STRINGDB
CTH
Tchem
Family:  Enzyme
Novelty:  0.0017155
Score:  0.946
Data Source:  STRINGDB
Pathways (21)
Branched-chain amino acid catabolism (R-HSA-70895)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Branched-chain amino acid catabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Branched-chain amino acid catabolism
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (78)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
3
8
7
2.3
99.3
alkaline phosphatase measurement
3
5
4
1.8
99.1
low density lipoprotein cholesterol measurement
5
10
14
98.6
apolipoprotein B measurement
2
5
5
97
reticulocyte measurement
3
5
6
96.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
7
2.3
99.3
alkaline phosphatase measurement
4
1.8
99.1
low density lipoprotein cholesterol measurement
14
98.6
apolipoprotein B measurement
5
97
reticulocyte measurement
6
96.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
branched chain amino acid transaminase 2
VGNC:8611
456189
Macaque
branched chain amino acid transaminase 2
718305
Mouse
MGI:1276534
12036
Rat
RGD:68948
64203
Dog
branched chain amino acid transaminase 2
VGNC:38402
484394
Species
Name
OMA
EggNOG
Inparanoid
Chimp
branched chain amino acid transaminase 2
Macaque
branched chain amino acid transaminase 2
Mouse
Rat
Dog
branched chain amino acid transaminase 2
Publication Statistics
PubMed Score 115.78
PubMed score by year
PubTator Score 34.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title