You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
BCAS2
Pre-mRNA-splicing factor SPF27

Protein Summary
Description
Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369541
  • ENSP00000358554
  • ENSG00000116752

Symbol
  • DAM1
  • DAM1
  • SPF27
  • Snt309
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.96
histone modification site profile
0.9
transcription factor binding site profile
0.82
tissue sample
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.71   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 320   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.71   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 320   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (291)
ZDBF2
Tdark
Novelty:  0.19205154
p_int:  0.999999798
p_ni:  2.01e-7
Data Source:  BioPlex
GPATCH1
Tdark
Novelty:  0.93318176
p_int:  0.999999603
p_ni:  3.97e-7
Data Source:  BioPlex
ZBTB8B
Tdark
Novelty:  5.22896463
p_int:  0.999999449
p_ni:  1.5e-8
p_wrong:  5.35e-7
Data Source:  BioPlex
LINS1
Tbio
Novelty:  0.00317377
p_int:  0.999998789
p_ni:  4.9e-8
p_wrong:  0.000001162
Data Source:  BioPlex
CWF19L2
Tdark
Novelty:  0.80210985
p_int:  0.999998032
p_ni:  0.000001968
Score:  0.67
Data Source:  BioPlex,STRINGDB
DHX35
Tdark
Family:  Enzyme
Novelty:  0.26052594
p_int:  0.999982729
p_ni:  0.000017271
Score:  0.396
Data Source:  BioPlex,STRINGDB
AQR
Tbio
Novelty:  0.00434312
p_int:  0.999972185
p_ni:  0.000027815
Score:  0.998
Data Source:  BioPlex,STRINGDB
XAB2
Tbio
Novelty:  0.04104647
p_int:  0.999958848
p_ni:  0.000041152
Score:  0.999
Data Source:  BioPlex,STRINGDB
ISY1
Tdark
Novelty:  1.68602768
p_int:  0.999949995
p_ni:  0.000050004
Score:  0.898
Data Source:  BioPlex,STRINGDB
CDC40
Tbio
Novelty:  0.03139044
p_int:  0.999872115
p_ni:  0.000127884
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
3
89.7
red blood cell distribution width
1
1
1
49.5
1
1
0
8.1
17.8
chronotype measurement
1
1
1
3.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
89.7
red blood cell distribution width
1
49.5
0
8.1
17.8
chronotype measurement
1
3.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BCAS2, pre-mRNA processing factor
VGNC:14799
457143
Mouse
MGI:1915433
68183
Rat
RGD:1306485
295334
Dog
BCAS2, pre-mRNA processing factor
VGNC:38399
475805
Horse
BCAS2, pre-mRNA processing factor
VGNC:15783
100065284
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BCAS2, pre-mRNA processing factor
Mouse
Rat
Dog
BCAS2, pre-mRNA processing factor
Horse
BCAS2, pre-mRNA processing factor
Publication Statistics
PubMed Score 21.71
PubMed score by year
PubTator Score 27.42
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title