Tbio BCAR3 Breast cancer anti-estrogen resistance protein 3

Protein Summary

Description

May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins. Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Uniprot Accession IDs

• O75815
• D3DT43
• Q5TEW3
• Q6UW40
• Q9BR50

Gene Name

• BCAR3

Ensembl ID

• ENST00000260502
• ENSP00000260502
• ENSG00000137936
• ENST00000370243
• ENSP00000359263
• ENST00000370244
• ENSP00000359264
• ENST00000370247
• ENSP00000359267
• ENST00000539242
• ENSP00000441343

Symbol

• NSP2
• SH2D3B
• NSP2
• AND-34
• SH2D3B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.88
transcription factor binding site profile	0.85
gene perturbation	0.71
PubMedID	0.71
tissue sample	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.05   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 140   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.05   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0