BCAN
Brevican core protein
Protein Summary
May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
- ENST00000329117
- ENSP00000331210
- ENSG00000132692
- ENST00000361588
- ENSP00000354925
- BEHAB
- CSPG7
- BEHAB
- CSPG7
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
pathway | 0.67 | ||
PubMedID | 0.67 | ||
cellular component | 0.66 | ||
transcription factor perturbation | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 137.09 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 184 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 137.09 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 184 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (110)
VCAN
Novelty: 0.00110986
p_int: 0.99999445
p_ni: 0.000005493
p_wrong: 5.7e-8
Score: 0.972
Data Source: BioPlex,STRINGDB
ULK3
Family: Kinase
Novelty: 0.0783598
p_int: 0.99997977
p_ni: 3.5e-8
p_wrong: 0.000020195
Score: 0.622
Data Source: BioPlex,STRINGDB
CCNYL1
Novelty: 0.45350824
p_int: 0.98083866
p_ni: 0.019155339
p_wrong: 0.000006002
Score: 0.234
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (23)
Reactome (21)
PathwayCommons (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | A tetrasaccharide linker sequence is required for GAG synthesis | ||||
Reactome | CS/DS degradation | ||||
Reactome | Chondroitin sulfate biosynthesis | ||||
Reactome | Chondroitin sulfate/dermatan sulfate metabolism | ||||
Reactome | Defective B3GALT6 causes EDSP2 and SEMDJL1 | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
A tetrasaccharide linker sequence is required for GAG synthesis | ||||
CS/DS degradation | ||||
Chondroitin sulfate biosynthesis | ||||
Chondroitin sulfate/dermatan sulfate metabolism | ||||
Defective B3GALT6 causes EDSP2 and SEMDJL1 | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (2)
Components (6)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 2 | 1 | 2 | 21.5 | |||||
platelet crit | 1 | 1 | 1 | 13.6 | |||||
bilirubin measurement | 1 | 1 | 1 | 4.8 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 2 | 21.5 | |||||
platelet crit | 1 | 13.6 | |||||
bilirubin measurement | 1 | 4.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | brevican | VGNC:455 | 457401 | |||||
Macaque | brevican | 718545 | ||||||
Mouse | MGI:1096385 | 12032 | ||||||
Rat | RGD:2194 | 25393 | ||||||
Dog | brevican | VGNC:38395 | 612102 | |||||
Publication Statistics
PubMed Score 137.09
PubMed score by year
PubTator Score 20.63
PubTator score by year
Related Publications
Text Mined References (23)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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