Tbio BCAM Basal cell adhesion molecule

Protein Summary

Description

Laminin alpha-5 receptor. May mediate intracellular signaling. This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Uniprot Accession IDs

• P50895
• A8MYF9
• A9YWT5
• A9YWT6
• Q86VC7

Gene Name

• BCAM

Ensembl ID

• ENST00000270233
• ENSP00000270233
• ENSG00000187244

Symbol

• LU
• MSK19
• AU
• LU
• CD239
• MSK19

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.82
transcription factor perturbation	0.74
protein domain	0.73
tissue sample	0.72
gene perturbation	0.7

Protein Classes

PANTHER Classes

Protein / Receptor / Basal Cell Adhesion Molecule

Protein / Cell Adhesion Molecule / Immunoglobulin Superfamily Cell Adhesion Molecule / Basal Cell Adhesion Molecule

DTO Classes

Protein / Cell Adhesion / Immunoglobulin Superfamily Cell Adhesion Molecule / Basal Cell Adhesion Molecule

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.82   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 354   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.82   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 354   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (52)

Explore Interacting Targets

1 – 10 of 52

• See Interactions on String-DB

LAMA4

Tbio

Novelty:  0.01288371

p_int:  0.999999925

p_ni:  7.4e-8

Score:  0.252

Data Source:  BioPlex,STRINGDB

ZSWIM2

Tbio

Family:  Enzyme

Novelty:  0.02135835

p_int:  0.999984337

p_ni:  0.000015658

p_wrong:  5e-9

Score:  0.189

Data Source:  BioPlex,STRINGDB

ARNTL

Tbio

Family:  TF

Novelty:  0.00102829

p_int:  0.999873472

p_ni:  0.000126528

Score:  0.189

Data Source:  BioPlex,STRINGDB

CLEC4A

Tbio

Novelty:  0.01821643

p_int:  0.999647758

p_ni:  0.000352207

p_wrong:  3.5e-8

Data Source:  BioPlex

EPHA7

Tchem

Family:  Kinase

Novelty:  0.01065563

p_int:  0.999419384

p_ni:  0.000580616

Data Source:  BioPlex

CTLA4

Tclin

Novelty:  0.00012781

p_int:  0.998282818

p_ni:  0.001717172

p_wrong:  1e-8

Data Source:  BioPlex

UPK2

Tbio

Novelty:  0.01066132

p_int:  0.997637444

p_ni:  0.002350396

p_wrong:  0.00001216

Data Source:  BioPlex

ATP6V0A1

Tbio

Family:  Enzyme

Novelty:  0.02009317

p_int:  0.994972939

p_ni:  0.005027061

Data Source:  BioPlex

TMEM11

Tbio

Novelty:  0.00067837

p_int:  0.993520126

p_ni:  0.006447687

p_wrong:  0.000032187

Data Source:  BioPlex

LAMA5

Tbio

Novelty:  0.02247145

p_int:  0.993022444

p_ni:  0.0069775

p_wrong:  5.6e-8

Score:  0.727

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (13)

Functions (4)

Components (6)

Processes (3)

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1 – 4 of 4

GO Term	Evidence	Assigned by
protein C-terminus binding	Inferred from Direct Assay (IDA)	CACAO
laminin binding	Inferred from Mutant Phenotype (IMP)	BHF-UCL
laminin receptor activity	Inferred from Mutant Phenotype (IMP)	BHF-UCL
transmembrane signaling receptor activity	Traceable Author Statement (TAS)	ProtInc

Disease Associations ()

No disease associations found

GWAS Traits (121)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 121

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
low density lipoprotein cholesterol measurement	EFO_0004611	35	73	114	7.4	100
apolipoprotein B measurement	EFO_0004615	2	61	62		100
total cholesterol measurement	EFO_0004574	21	61	93	6.8	100
C-reactive protein measurement	EFO_0004458	14	53	69	21.8	100
Alzheimer's disease	EFO_0000249	27	64	2	2.8	99.9

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 121

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
low density lipoprotein cholesterol measurement	EFO_0004611	114	7.4	100
apolipoprotein B measurement	EFO_0004615	62		100
total cholesterol measurement	EFO_0004574	93	6.8	100
C-reactive protein measurement	EFO_0004458	69	21.8	100
Alzheimer's disease	EFO_0000249	2	2.8	99.9

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Blood group antigen
Cell adhesion
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
Abdominal Aortic Aneurysm
age at onset
age-related macular degeneration
Agents acting on the renin-angiotensin system use measurement
alkaline phosphatase measurement
Alzheimer's disease
amyloid-beta measurement
Antithrombotic agent use measurement
apolipoprotein A 1 measurement
apolipoprotein B measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
digestive/alimentary phenotype
growth/size/body region phenotype
renal/urinary system phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	basal cell adhesion molecule	VGNC:2582	744276
Macaque	basal cell adhesion molecule (Lutheran blood group)		714568
Mouse	basal cell adhesion molecule	MGI:1929940	57278
Rat	basal cell adhesion molecule (Lutheran blood group)	RGD:68378	78958
Dog	basal cell adhesion molecule	VGNC:49023	484456

Species	Name	OMA	EggNOG	Inparanoid
Chimp	basal cell adhesion molecule
Macaque	basal cell adhesion molecule (Lutheran blood group)
Mouse	basal cell adhesion molecule
Rat	basal cell adhesion molecule (Lutheran blood group)
Dog	basal cell adhesion molecule

Publication Statistics

PubMed Score 66.82

PubMed score by year

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PubTator Score 127.78

PubTator score by year

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Related Publications

Text Mined References (72)

GeneRif Annotations (35)

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10

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PMID	Year	Title