You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
BBS10
Bardet-Biedl syndrome 10 protein

Protein Summary
Description
Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis (PubMed:20080638). Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). Involved in adipogenic differentiation (PubMed:19190184). This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and cognitive disability. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393262
  • ENSP00000376946
  • ENSG00000179941
  • ENST00000650064
  • ENSP00000497413

Symbol
  • C12orf58
  • C12orf58
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
molecular function
0.86
histone modification site profile
0.78
transcription factor binding site profile
0.62
phenotype
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.92   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.92   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (389)
BBS7
Tbio
Novelty:  0.03611111
p_int:  0.99999556
p_ni:  0.000004424
p_wrong:  1.7e-8
Score:  0.993
Data Source:  BioPlex,STRINGDB
DNAJC7
Tbio
Novelty:  0.02133191
p_int:  0.999988044
p_ni:  0.000011906
p_wrong:  5e-8
Score:  0.237
Data Source:  BioPlex,STRINGDB
SSSCA1
Tdark
Novelty:  0.53523038
p_int:  0.989995159
p_ni:  0.000002161
p_wrong:  0.01000268
Score:  0.371
Data Source:  BioPlex,STRINGDB
HSP90AA4P
Tdark
p_int:  0.950911482
p_ni:  0.049088517
p_wrong:  1e-9
Data Source:  BioPlex
CCT3
Tbio
Novelty:  0.01642521
Score:  0.999
Data Source:  STRINGDB
CCT4
Tbio
Novelty:  0.01176123
Score:  0.999
Data Source:  STRINGDB
CCT2
Tbio
Novelty:  0.01967139
Score:  0.999
Data Source:  STRINGDB
CCT8
Tbio
Novelty:  0.03168289
Score:  0.999
Data Source:  STRINGDB
MKKS
Tbio
Novelty:  0.00805347
Score:  0.997
Data Source:  STRINGDB
BBS12
Tbio
Novelty:  0.06131428
Score:  0.995
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
BBSome-mediated cargo-targeting to cilium (R-HSA-5620922)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
BBSome-mediated cargo-targeting to cilium
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
BBSome-mediated cargo-targeting to cilium
Cargo trafficking to the periciliary membrane
Cilium Assembly
Organelle biogenesis and maintenance
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Bardet-Biedl syndrome 10
452084
Mouse
MGI:1919019
71769
Rat
RGD:1560748
500832
Dog
Bardet-Biedl syndrome 10
100688777
Horse
Bardet-Biedl syndrome 10
100058970
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Bardet-Biedl syndrome 10
Mouse
Rat
Dog
Bardet-Biedl syndrome 10
Horse
Bardet-Biedl syndrome 10
Publication Statistics
PubMed Score 39.92
PubMed score by year
PubTator Score 16.78
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title