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Tdark
BBOF1
Basal body-orientation factor 1

Protein Summary
Description
Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabilizes and aligns cilia orientation. Not required to respond to planar cell polarity (PCP) or flow-based orientation cues (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394009
  • ENSP00000377577
  • ENSG00000119636

Symbol
  • C14orf45
  • CCDC176
  • CCDC176
  • C14orf45
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.26   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.26   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (9)
FBXO36
Tdark
Novelty:  1.95826259
Score:  0.707
Data Source:  STRINGDB
CCDC78
Tbio
Novelty:  0.26467655
Score:  0.657
Data Source:  STRINGDB
C1orf74
Tdark
Novelty:  4.51963746
Score:  0.646
Data Source:  STRINGDB
CEP135
Tbio
Novelty:  0.03507768
Score:  0.605
Data Source:  STRINGDB
AGPS
Tbio
Family:  Enzyme
Novelty:  0.01075549
Score:  0.5
Data Source:  STRINGDB
PHF20
Tbio
Family:  Epigenetic
Novelty:  0.01961423
Score:  0.492
Data Source:  STRINGDB
ICE2
Tbio
Novelty:  0.03407933
Score:  0.424
Data Source:  STRINGDB
TRAF3IP3
Tbio
Novelty:  0.12180834
Score:  0.424
Data Source:  STRINGDB
CPLANE2
Tdark
Family:  Enzyme
Novelty:  0.04171418
Score:  0.4
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
3
5
97.8
ganglion cell inner plexiform layer thickness measurement
1
1
1
59
self reported educational attainment
1
1
1
40.7
mean corpuscular volume
1
1
1
39.6
mean reticulocyte volume
1
1
1
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
5
97.8
ganglion cell inner plexiform layer thickness measurement
1
59
self reported educational attainment
1
40.7
mean corpuscular volume
1
39.6
mean reticulocyte volume
1
26.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
basal body orientation factor 1
VGNC:3473
453029
Mouse
MGI:1920123
72873
Dog
basal body orientation factor 1
VGNC:38392
611882
Horse
basal body orientation factor 1
VGNC:15776
100056509
Cow
basal body orientation factor 1
VGNC:26431
100137993
Species
Name
OMA
EggNOG
Inparanoid
Chimp
basal body orientation factor 1
Mouse
Dog
basal body orientation factor 1
Horse
basal body orientation factor 1
Cow
basal body orientation factor 1
Publication Statistics
PubMed Score 1.26
PubMed score by year
PubTator Score 1.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title