BBOF1
Basal body-orientation factor 1
Protein Summary
Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabilizes and aligns cilia orientation. Not required to respond to planar cell polarity (PCP) or flow-based orientation cues (By similarity).
- ENST00000394009
- ENSP00000377577
- ENSG00000119636
- C14orf45
- CCDC176
- CCDC176
- C14orf45
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.26 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 31 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.26 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 31 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (9)
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (3)
Components (2)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 4 | 3 | 5 | 97.8 | |||||
ganglion cell inner plexiform layer thickness measurement | 1 | 1 | 1 | 59 | |||||
self reported educational attainment | 1 | 1 | 1 | 40.7 | |||||
mean corpuscular volume | 1 | 1 | 1 | 39.6 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 26.6 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
red blood cell distribution width | 5 | 97.8 | |||||
ganglion cell inner plexiform layer thickness measurement | 1 | 59 | |||||
self reported educational attainment | 1 | 40.7 | |||||
mean corpuscular volume | 1 | 39.6 | |||||
mean reticulocyte volume | 1 | 26.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | basal body orientation factor 1 | VGNC:3473 | 453029 | |||||
Mouse | MGI:1920123 | 72873 | ||||||
Dog | basal body orientation factor 1 | VGNC:38392 | 611882 | |||||
Horse | basal body orientation factor 1 | VGNC:15776 | 100056509 | |||||
Cow | basal body orientation factor 1 | VGNC:26431 | 100137993 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | basal body orientation factor 1 | |||||
Mouse | ||||||
Dog | basal body orientation factor 1 | |||||
Horse | basal body orientation factor 1 | |||||
Cow | basal body orientation factor 1 | |||||
Publication Statistics
PubMed Score 1.26
PubMed score by year
PubTator Score 1.00
PubTator score by year
Related Publications
Text Mined References (6)
Items per page:
0 of 0
PMID | Year | Title |
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