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Tchem
BAZ1A
Bromodomain adjacent to zinc finger domain protein 1A

Protein Summary
Description
Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end-positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression. Component of the histone-fold protein complex CHRAC complex which facilitates nucleosome sliding by the ACF complex and enhances ACF-mediated chromatin assembly. The C-terminal regions of both CHRAC1 and POLE1 are required for these functions. The BAZ1A gene encodes the accessory subunit of the ATP-dependent chromati ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358716
  • ENSP00000351555
  • ENSG00000198604
  • ENST00000360310
  • ENSP00000353458
  • ENST00000382422
  • ENSP00000371859

Symbol
  • ACF1
  • WCRF180
  • ACF1
  • WALp1
  • hACF1
  • WCRF180
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
interacting protein
0.98
virus perturbation
0.92
transcription factor perturbation
0.88
drug perturbation
0.87


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.71   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.71   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0