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Tbio
BATF3
Basic leucine zipper transcriptional factor ATF-like 3

Protein Summary
Description
AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. This gene encodes a member of the basic leucine zipper protein family. The encoded protein functions as a transcriptional repressor when heterodimerizing with JUN. The protein may play a role in repression of interleukin-2 and matrix metalloproteinase-1 transcription.[provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243440
  • ENSP00000243440
  • ENSG00000123685

Symbol
  • SNFT
  • JDP1
  • SNFT
  • JUNDM1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
histone modification site profile
0.85
biological process
0.66
cell type or tissue
0.65
tissue sample
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.74   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.74   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (90)
JUNB
Tbio
Family:  TF
Novelty:  0.00841656
p_int:  1
Score:  0.876
Data Source:  BioPlex,STRINGDB
BACH2
Tbio
Family:  TF
Novelty:  0.00932069
p_int:  0.999999759
p_ni:  2.41e-7
Score:  0.41
Data Source:  BioPlex,STRINGDB
ATF7
Tbio
Family:  TF
Novelty:  0.01470313
p_int:  0.99999923
p_ni:  7.7e-7
Score:  0.702
Data Source:  BioPlex,STRINGDB
RTL6
Tbio
Novelty:  0.12824182
p_int:  0.999998562
p_ni:  7.84e-7
p_wrong:  6.53e-7
Score:  0.571
Data Source:  BioPlex,STRINGDB
ZNF451
Tbio
Family:  TF
Novelty:  0.13852406
p_int:  0.999998032
p_ni:  0.000001342
p_wrong:  6.26e-7
Score:  0.348
Data Source:  BioPlex,STRINGDB
JUND
Tbio
Family:  TF
Novelty:  0.00277701
p_int:  0.999997697
p_ni:  0.00000217
p_wrong:  1.33e-7
Score:  0.898
Data Source:  BioPlex,STRINGDB
ATF2
Tbio
Family:  TF
Novelty:  0.00457832
p_int:  0.999997207
p_ni:  0.000002793
p_wrong:  1e-9
Score:  0.682
Data Source:  BioPlex,STRINGDB
BACH1
Tbio
Family:  TF
Novelty:  0.04011328
p_int:  0.999996282
p_ni:  0.000003708
p_wrong:  1e-8
Score:  0.216
Data Source:  BioPlex,STRINGDB
ZBTB10
Tbio
Family:  TF
Novelty:  0.05707286
p_int:  0.999994371
p_ni:  0.000005621
p_wrong:  7e-9
Score:  0.209
Data Source:  BioPlex,STRINGDB
JUN
Tchem
Family:  TF
Novelty:  0.00006856
p_int:  0.999968347
p_ni:  0.000031652
p_wrong:  1e-9
Score:  0.991
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
1
1
1
21.5
1
1
0
1
15.8
1
1
0
1.1
13.7
lymphocyte percentage of leukocytes
1
1
1
11.6
neutrophil percentage of leukocytes
1
1
1
11.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
1
21.5
0
1
15.8
0
1.1
13.7
lymphocyte percentage of leukocytes
1
11.6
neutrophil percentage of leukocytes
1
11.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
basic leucine zipper ATF-like transcription factor 3
VGNC:11734
457721
Macaque
basic leucine zipper ATF-like transcription factor 3
710551
Mouse
MGI:1925491
381319
Rat
RGD:620501
60462
Dog
basic leucine zipper ATF-like transcription factor 3
VGNC:38387
490283
Species
Name
OMA
EggNOG
Inparanoid
Chimp
basic leucine zipper ATF-like transcription factor 3
Macaque
basic leucine zipper ATF-like transcription factor 3
Mouse
Rat
Dog
basic leucine zipper ATF-like transcription factor 3
Publication Statistics
PubMed Score 76.74
PubMed score by year
PubTator Score 20.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title