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Tbio
BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

Protein Summary
Description
Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytopla ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000460680
  • ENSP00000417132
  • ENSG00000163930

Symbol
  • KIAA0272
  • UCHL2
  • hucep-6
  • HUCEP-13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.83
histone modification site profile
0.79
transcription factor perturbation
0.74
cell type or tissue
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.27   (req: < 5)
Gene RIFs: 187   (req: <= 3)
Antibodies: 387   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.27   (req: >= 5)
Gene RIFs: 187   (req: > 3)
Antibodies: 387   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (134)
ASXL1
Tbio
Family:  Epigenetic
Novelty:  0.00342965
p_int:  0.999999998
p_ni:  2e-9
p_wrong:  1e-9
Score:  0.978
Data Source:  BioPlex,Reactome,STRINGDB
ASXL3
Tbio
Family:  Epigenetic
Novelty:  0.03722366
p_int:  0.999999911
p_ni:  6e-9
p_wrong:  8.3e-8
Score:  0.806
Data Source:  BioPlex,STRINGDB
KDM1B
Tbio
Family:  Epigenetic
Novelty:  0.02174039
p_int:  0.999999907
p_ni:  9.3e-8
Score:  0.956
Data Source:  BioPlex,STRINGDB
ASXL2
Tbio
Family:  Epigenetic
Novelty:  0.04277784
p_int:  0.999999887
p_ni:  1.13e-7
Score:  0.983
Data Source:  BioPlex,Reactome,STRINGDB
MBD5
Tbio
Family:  Epigenetic
Novelty:  0.03015349
p_int:  0.999999836
p_ni:  1.5e-8
p_wrong:  1.5e-7
Score:  0.933
Data Source:  BioPlex,STRINGDB
PSME3
Tbio
Novelty:  0.01051254
p_int:  0.999999676
p_ni:  3.24e-7
Score:  0.162
Data Source:  BioPlex,STRINGDB
FOXK2
Tbio
Family:  TF
Novelty:  0.01420141
p_int:  0.999999624
p_ni:  3.76e-7
Score:  0.969
Data Source:  BioPlex,Reactome,STRINGDB
GOPC
Tbio
Novelty:  0.01110168
p_int:  0.999995523
p_ni:  0.000004458
p_wrong:  1.8e-8
Score:  0.181
Data Source:  BioPlex,STRINGDB
FOXK1
Tbio
Family:  TF
Novelty:  0.01321144
p_int:  0.999988043
p_ni:  0.000011957
Score:  0.965
Data Source:  BioPlex,Reactome,STRINGDB
CAMK2D
Tchem
Family:  Kinase
Novelty:  0.02326864
p_int:  0.99997876
p_ni:  0.000021239
p_wrong:  1e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
DNA Double Strand Break Response (R-HSA-5693606)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double Strand Break Response
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
DNA Double Strand Break Response
DNA Double-Strand Break Repair
DNA Repair
Deubiquitination
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
5
5
94.5
high density lipoprotein cholesterol measurement
6
6
8
92.2
urate measurement
1
4
4
92.2
BMI-adjusted waist circumference
2
8
8
89.4
BMI-adjusted waist-hip ratio
1
9
9
88.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
5
94.5
high density lipoprotein cholesterol measurement
8
92.2
urate measurement
4
92.2
BMI-adjusted waist circumference
8
89.4
BMI-adjusted waist-hip ratio
9
88.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BRCA1 associated protein 1
VGNC:5025
460426
Macaque
BRCA1 associated protein 1
697221
Mouse
MGI:1206586
104416
Rat
RGD:1311938
306257
Dog
BRCA1 associated protein 1
VGNC:38379
484737
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BRCA1 associated protein 1
Macaque
BRCA1 associated protein 1
Mouse
Rat
Dog
BRCA1 associated protein 1
Publication Statistics
PubMed Score 242.27
PubMed score by year
PubTator Score 354.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title