Tbio BANP Protein BANP

Protein Summary

Description

Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity). This gene encodes a protein that binds to matrix attachment regions. The protein forms a complex with p53 and negatively regulates p53 transcription, and functions as a tumor suppressor and cell cycle regulator. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q8N9N5
• A8MU25
• A8MX25
• B2RCF7
• B4DNJ9
• F5GZM0
• Q96GJ7
• Q9NWY1

Gene Name

• BANP

Ensembl ID

• ENST00000286122
• ENSP00000286122
• ENSG00000172530
• ENST00000355022
• ENSP00000347125
• ENST00000393207
• ENSP00000376902
• ENST00000393208
• ENSP00000376903
• ENST00000479780
• ENSP00000432508
• ENST00000538234
• ENSP00000444352
• ENST00000626016
• ENSP00000487304

Symbol

• BEND1
• SMAR1
• BEND1
• SMAR1
• SMARBP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.97
transcription factor binding site profile	0.97
transcription factor	0.79
cell type or tissue	0.77
tissue sample	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.72   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 125   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.72   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0