You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
BAK1
Bcl-2 homologous antagonist/killer

Protein Summary
Description
Plays a role in the mitochondrial apoptosic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases. The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374467
  • ENSP00000363591
  • ENSG00000030110
  • ENST00000442998
  • ENSP00000391258

Symbol
  • BAK
  • BCL2L7
  • CDN1
  • BAK
  • CDN1
  • BCL2L7
  • BAK-LIKE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
virus
1
viral protein
0.98
chemical
0.96
cellular component
0.89


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.93   (req: < 5)
Gene RIFs: 203   (req: <= 3)
Antibodies: 681   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.93   (req: >= 5)
Gene RIFs: 203   (req: > 3)
Antibodies: 681   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 61
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (84)
MCL1
Tchem
Novelty:  0.00046181
p_int:  0.999999998
p_wrong:  2e-9
Score:  0.965
Data Source:  BioPlex,STRINGDB
BCL2L1
Tchem
Novelty:  0.00018414
Score:  0.998
Data Source:  STRINGDB
BCL2L11
Tchem
Novelty:  0.00055914
Score:  0.996
Data Source:  STRINGDB
BID
Tbio
Novelty:  0.01264688
Score:  0.995
Data Source:  Reactome,STRINGDB
BCL2
Tclin
Novelty:  0.00608635
Score:  0.984
Data Source:  STRINGDB
APAF1
Tchem
Family:  Enzyme
Novelty:  0.00107622
Score:  0.978
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.975
Data Source:  STRINGDB
CYCS
Tchem
Novelty:  0.00014004
Score:  0.958
Data Source:  STRINGDB
BAX
Tchem
Novelty:  0.00150653
Score:  0.952
Data Source:  STRINGDB
DIABLO
Tbio
Novelty:  0.0007851
Score:  0.944
Data Source:  STRINGDB
Pathways (88)
Activation and oligomerization of BAK protein (R-HSA-111452)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation and oligomerization of BAK protein
Reactome
Apoptosis
Reactome
Apoptotic factor-mediated response
Reactome
Intrinsic Pathway for Apoptosis
Reactome
Programmed Cell Death
Name
Explore in Pharos
Explore in Source
Activation and oligomerization of BAK protein
Apoptosis
Apoptotic factor-mediated response
Intrinsic Pathway for Apoptosis
Programmed Cell Death
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (68)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
13
14
8
5.7
99.8
platelet crit
2
4
4
98.8
eosinophil percentage of leukocytes
2
3
3
84.3
liver fibrosis measurement
3
3
9
84
mitochondrial DNA measurement
1
2
2
83.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
8
5.7
99.8
platelet crit
4
98.8
eosinophil percentage of leukocytes
3
84.3
liver fibrosis measurement
9
84
mitochondrial DNA measurement
2
83.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BCL2 antagonist/killer 1
VGNC:8158
462616
Macaque
BCL2 antagonist/killer 1
706534
Mouse
MGI:1097161
12018
Rat
RGD:621635
116502
Dog
BCL2 antagonist/killer 1
VGNC:38375
481744
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BCL2 antagonist/killer 1
Macaque
BCL2 antagonist/killer 1
Mouse
Rat
Dog
BCL2 antagonist/killer 1
Publication Statistics
PubMed Score 249.93
PubMed score by year
PubTator Score 611.34
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title