You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
BAIAP3
BAI1-associated protein 3

Protein Summary
Description
Functions in endosome to Golgi retrograde transport. In response to calcium influx, may interact with SNARE fusion receptors and membrane phospholipids to mediate endosome fusion with the trans-Golgi network. By promoting the recycling of secretory vesicle transmembrane proteins, it indirectly controls dense-core secretory vesicle biogenesis, maturation and their ability to mediate the constitutive and regulated secretion of neurotransmitters and hormones. May regulate behavior and food intake by controlling calcium-stimulated exocytosis of neurotransmitters including NPY and serotonin and hormones like insulin (PubMed:28626000). Proposed to play a role in hypothalamic neuronal firing by modulating gamma-aminobutyric acid (GABA)ergic inhibitory neurotransmission (By similarity). This p53-target gene encodes a brain-specific angiogenesis inhibitor. The protein is a seven-span transmembrane protein and a member of the secretin receptor family. It interacts with the cytoplasmic region of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324385
  • ENSP00000324510
  • ENSG00000007516
  • ENST00000397488
  • ENSP00000380625
  • ENST00000421665
  • ENSP00000409533
  • ENST00000426824
  • ENSP00000407242
  • ENST00000562208
  • ENSP00000458134
  • ENST00000568887
  • ENSP00000457644
  • ENST00000628027
  • ENSP00000487275

Symbol
  • KIAA0734
  • BAP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.64
cell line
0.61
transcription factor
0.61
protein domain
0.58
tissue
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.14   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.14   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0