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Tbio
BAG6
Large proline-rich protein BAG6

Protein Summary
Description
ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:28104892, PubMed:25535373). Client proteins that cannot be properly delivered to the en ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000211379
  • ENSP00000211379
  • ENSG00000204463
  • ENST00000361076
  • ENSP00000354368
  • ENSG00000096155
  • ENST00000362049
  • ENSP00000354875
  • ENST00000375964
  • ENSP00000365131
  • ENST00000375976
  • ENSP00000365143
  • ENST00000383446
  • ENSP00000372938
  • ENST00000383448
  • ENSP00000372940
  • ENST00000417144
  • ENSP00000412110
  • ENSG00000229524
  • ENST00000419847
  • ENSP00000389121
  • ENSG00000233348
  • ENST00000439687
  • ENSP00000402856
  • ENST00000442479
  • ENSP00000413698
  • ENST00000443182
  • ENSP00000410156
  • ENST00000449450
  • ENSP00000397894
  • ENST00000451932
  • ENSP00000390966
  • ENST00000551350
  • ENSP00000447546
  • ENST00000552116
  • ENSP00000447946
  • ENST00000552605
  • ENSP00000446525
  • ENST00000613474
  • ENSP00000478966
  • ENSG00000227761
  • ENST00000615143
  • ENSP00000482413
  • ENST00000615224
  • ENSP00000477951
  • ENSG00000228760
  • ENST00000615725
  • ENSP00000479238
  • ENST00000617635
  • ENSP00000484238
  • ENST00000621056
  • ENSP00000477867
  • ENSG00000234651

Symbol
  • BAT3
  • G3
  • G3
  • BAT3
  • BAG-6
  • D6S52E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
trait
0.93
biological process
0.86
protein complex
0.83
hub protein
0.82


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 342.17   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 272   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 342.17   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 272   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0