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Tbio
BAG6
Large proline-rich protein BAG6

Protein Summary
Description
ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:28104892, PubMed:25535373). Client proteins that cannot be properly delivered to the en ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000211379
  • ENSP00000211379
  • ENSG00000204463
  • ENST00000361076
  • ENSP00000354368
  • ENSG00000096155
  • ENST00000362049
  • ENSP00000354875
  • ENST00000375964
  • ENSP00000365131
  • ENST00000375976
  • ENSP00000365143
  • ENST00000383446
  • ENSP00000372938
  • ENST00000383448
  • ENSP00000372940
  • ENST00000417144
  • ENSP00000412110
  • ENSG00000229524
  • ENST00000419847
  • ENSP00000389121
  • ENSG00000233348
  • ENST00000439687
  • ENSP00000402856
  • ENST00000442479
  • ENSP00000413698
  • ENST00000443182
  • ENSP00000410156
  • ENST00000449450
  • ENSP00000397894
  • ENST00000451932
  • ENSP00000390966
  • ENST00000551350
  • ENSP00000447546
  • ENST00000552116
  • ENSP00000447946
  • ENST00000552605
  • ENSP00000446525
  • ENST00000613474
  • ENSP00000478966
  • ENSG00000227761
  • ENST00000615143
  • ENSP00000482413
  • ENST00000615224
  • ENSP00000477951
  • ENSG00000228760
  • ENST00000615725
  • ENSP00000479238
  • ENST00000617635
  • ENSP00000484238
  • ENST00000621056
  • ENSP00000477867
  • ENSG00000234651

Symbol
  • BAT3
  • G3
  • G3
  • BAT3
  • BAG-6
  • D6S52E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
trait
0.93
biological process
0.86
protein complex
0.83
hub protein
0.82


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.05   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 272   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.05   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 272   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (121)
UBL4B
Tdark
Novelty:  0.56877836
p_int:  0.999399467
p_ni:  0.000600533
Score:  0.243
Data Source:  BioPlex,STRINGDB
UBL4A
Tbio
Novelty:  0.01278608
p_int:  0.992479775
p_ni:  0.007520225
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
RNF126
Tbio
Family:  Enzyme
Novelty:  0.08123801
p_int:  0.988185933
p_ni:  0.011814067
Score:  0.969
Data Source:  BioPlex,STRINGDB
FUZ
Tbio
Novelty:  0.03001976
p_int:  0.943453605
p_ni:  0.056546395
Score:  0.571
Data Source:  BioPlex,STRINGDB
IL17RC
Tclin
Novelty:  0.01844832
p_int:  0.840178363
p_ni:  0.159821637
Score:  0.222
Data Source:  BioPlex,STRINGDB
CCNQ
Tdark
Novelty:  0.08298637
p_int:  0.833896157
p_ni:  0.166103843
Score:  0.28
Data Source:  BioPlex,STRINGDB
GET4
Tbio
Novelty:  0.03516005
p_int:  0.820876519
p_ni:  0.179123481
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
KIR2DL4
Tbio
Novelty:  0.00163053
Score:  0.862
Data Source:  STRINGDB
C6orf48
Tdark
Novelty:  0.00615017
Score:  0.839
Data Source:  STRINGDB
CLIC1
Tbio
Family:  IC
Novelty:  0.00622691
Score:  0.837
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane (R-HSA-9609523)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Protein localization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (45)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (630)
Items per page:
1 – 5 of 630
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
3
0
3
96.3
1
3
0
3
96.3
1
3
0
3
96.3
1
3
0
3
96.3
1
3
0
3
96.3
Items per page:
1 – 5 of 630
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
3
96.3
0
3
96.3
0
3
96.3
0
3
96.3
0
3
96.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1919439
224727
Rat
RGD:71064
94342
Dog
BCL2 associated athanogene 6
VGNC:38368
474842
Horse
BCL2 associated athanogene 6
VGNC:15756
100050296
Cow
BCL2 associated athanogene 6
VGNC:26410
508605
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
BCL2 associated athanogene 6
Horse
BCL2 associated athanogene 6
Cow
BCL2 associated athanogene 6
Publication Statistics
PubMed Score 245.05
PubMed score by year
PubTator Score 280.35
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title