Tchem BAD Bcl2-associated agonist of cell death

Protein Summary

Description

Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q92934
• O14803
• Q6FH21
• BAD

Gene Name

• BAD

Ensembl ID

• ENST00000309032
• ENSP00000309103
• ENSG00000002330
• ENST00000394532
• ENSP00000378040

Symbol

• BBC6
• BCL2L8
• BBC2
• BCL2L8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
chemical	1
kinase	1
phosphatase	1
hub protein	0.99

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.88   (req: < 5)

Gene RIFs: 171   (req: <= 3)

Antibodies: 2933   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.88   (req: >= 5)

Gene RIFs: 171   (req: > 3)

Antibodies: 2933   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 65

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 37

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1