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Tbio
BABAM1
BRISC and BRCA1-A complex member 1

Protein Summary
Description
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359435
  • ENSP00000352408
  • ENSG00000105393
  • ENST00000598188
  • ENSP00000471605
  • ENST00000601043
  • ENSP00000470920

Symbol
  • C19orf62
  • MERIT40
  • NBA1
  • NBA1
  • HSPC142
  • MERIT40
  • C19orf62
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
interacting protein
0.84
histone modification site profile
0.74
cell type or tissue
0.73
protein complex
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.49   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.49   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (106)
ABRAXAS1
Tbio
Novelty:  0.07078408
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
UIMC1
Tbio
Novelty:  0.02039732
p_int:  0.99999986
p_ni:  1.22e-7
p_wrong:  1.8e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
TNKS2
Tchem
Family:  Enzyme
Novelty:  0.00938509
p_int:  0.999999654
p_ni:  3.46e-7
Score:  0.341
Data Source:  BioPlex,STRINGDB
TNKS
Tchem
Family:  Enzyme
Novelty:  0.00404545
p_int:  0.999999647
p_ni:  3.53e-7
Score:  0.565
Data Source:  BioPlex,STRINGDB
BABAM2
Tbio
Novelty:  0.00448485
p_int:  0.999999045
p_ni:  9.54e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ABRAXAS2
Tbio
Novelty:  0.20430604
p_int:  0.999993372
p_ni:  0.000006628
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
BRCC3
Tbio
Family:  Enzyme
Novelty:  0.04661632
p_int:  0.999866538
p_ni:  0.000133462
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
DEF6
Tbio
Novelty:  0.0378487
p_int:  0.999749468
p_ni:  0.000250532
Score:  0.692
Data Source:  BioPlex,STRINGDB
C9orf85
Tdark
Novelty:  4.61061386
p_int:  0.999433093
p_ni:  0.000566576
p_wrong:  3.31e-7
Data Source:  BioPlex
DNAJC25
Tdark
Novelty:  1.55044803
p_int:  0.999146998
p_ni:  0.00085299
p_wrong:  1.2e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
DNA Double Strand Break Response
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
DNA Double Strand Break Response
DNA Double-Strand Break Repair
DNA Repair
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
2
8
95.9
testosterone measurement
5
3
5
95.6
6
4
0
1.2
93.9
2
3
0
1.2
92.6
mitochondrial DNA measurement
2
3
3
90
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
8
95.9
testosterone measurement
5
95.6
0
1.2
93.9
0
1.2
92.6
mitochondrial DNA measurement
3
90
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BRISC and BRCA1 A complex member 1
VGNC:11226
455827
Macaque
BRISC and BRCA1 A complex member 1
718969
Mouse
MGI:1915501
68251
Rat
RGD:1359516
290631
Dog
BRISC and BRCA1 A complex member 1
476676
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BRISC and BRCA1 A complex member 1
Macaque
BRISC and BRCA1 A complex member 1
Mouse
Rat
Dog
BRISC and BRCA1 A complex member 1
Publication Statistics
PubMed Score 26.49
PubMed score by year
PubTator Score 10.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title