Tbio BAAT Bile acid-CoA:amino acid N-acyltransferase

Protein Summary

Description

Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs. The protein encoded by this gene is a liver enzyme that catalyzes the transfer of C24 bile acids from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates. The bile acid conjugates then act as a detergent in the gastrointestinal tract, which enhances lipid and fat-soluble vitamin absorption. Defects in this gene are a cause of familial hypercholanemia (FHCA). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q14032
• Q3B7W9
• Q96L31
• BACAT

Gene Name

• BAAT

Ensembl ID

• ENST00000259407
• ENSP00000259407
• ENSG00000136881
• ENST00000395051
• ENSP00000378491
• ENST00000621712
• ENSP00000484063
• ENSG00000276559

Symbol

• BAT
• BACAT

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.71
molecular function	0.7
cell type or tissue	0.68
disease perturbation	0.68
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.44   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 182   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.44   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (96)

Explore Interacting Targets

1 – 10 of 96

• See Interactions on String-DB

STAU1

Tbio

Novelty:  0.00565778

p_int:  0.896207965

p_ni:  0.103792035

Score:  0.214

Data Source:  BioPlex,STRINGDB

ACOT8

Tbio

Family:  Enzyme

Novelty:  0.02218214

Score:  0.967

Data Source:  STRINGDB

HAO2

Tchem

Family:  Enzyme

Novelty:  0.03029536

Score:  0.966

Data Source:  STRINGDB

SLC27A5

Tbio

Family:  Transporter

Novelty:  0.01631425

Score:  0.965

Data Source:  STRINGDB

HAO1

Tclin

Family:  Enzyme

Novelty:  0.00054723

Score:  0.965

Data Source:  STRINGDB

LONP2

Tbio

Family:  Enzyme

Novelty:  0.04499043

Score:  0.963

Data Source:  STRINGDB

EHHADH

Tbio

Novelty:  0.00878193

Score:  0.961

Data Source:  STRINGDB

GNPAT

Tchem

Family:  Enzyme

Novelty:  0.01255689

Score:  0.958

Data Source:  STRINGDB

PECR

Tbio

Family:  Enzyme

Novelty:  0.01550165

Score:  0.957

Data Source:  STRINGDB

ECH1

Tbio

Family:  Enzyme

Novelty:  0.02471875

Score:  0.951

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (21)

Reactome (9)

KEGG (6)

PathwayCommons (1)

WikiPathways (5)

Bile acid and bile salt metabolism (R-HSA-194068)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Bile acid and bile salt metabolism	43 targets	R-HSA-194068
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833
Reactome	Metabolism of steroids	151 targets	R-HSA-8957322
Reactome	Peroxisomal protein import	63 targets	R-HSA-9033241

Name	Explore in Pharos	Explore in Source
Bile acid and bile salt metabolism	43 targets	R-HSA-194068
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833
Metabolism of steroids	151 targets	R-HSA-8957322
Peroxisomal protein import	63 targets	R-HSA-9033241

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (24)

Functions (11)

Components (3)

Processes (10)

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10

1 – 10 of 11

GO Term	Evidence	Assigned by
glycine N-choloyltransferase activity	Inferred from Direct Assay (IDA)	UniProtKB
long-chain acyl-CoA hydrolase activity	Inferred from Direct Assay (IDA)	UniProtKB
medium-chain acyl-CoA hydrolase activity	Inferred from Direct Assay (IDA)	UniProtKB
N-acyltransferase activity	Inferred from Direct Assay (IDA)	MGI
very long chain acyl-CoA hydrolase activity	Inferred from Direct Assay (IDA)	UniProtKB
signaling receptor binding	Inferred from Physical Interaction (IPI)	UniProtKB
acyl-CoA hydrolase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
transferase activity, transferring acyl groups	Traceable Author Statement (TAS)	Reactome
carboxylic ester hydrolase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
myristoyl-CoA hydrolase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

Disease Associations (null)

No disease associations found

GWAS Traits (4)

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1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
alkaline phosphatase measurement	EFO_0004533	4	3	3	9.9	95.9
C-reactive protein measurement	EFO_0004458	1	1	1		59
creatinine measurement	EFO_0004518	1	1	1		49.5
glomerular filtration rate	EFO_0005208	1	1	1		46.9

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
alkaline phosphatase measurement	EFO_0004533	3	9.9	95.9
C-reactive protein measurement	EFO_0004458	1		59
creatinine measurement	EFO_0004518	1		49.5
glomerular filtration rate	EFO_0005208	1		46.9

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UniProt Keyword Find Similar Targets

No Header	No Header
Acyltransferase
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Fatty acid metabolism
Hydrolase
Lipid metabolism
Phosphoprotein
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
alkaline phosphatase measurement
C-reactive protein measurement
creatinine measurement
glomerular filtration rate

MGI Phenotype Find Similar Targets

No Header	No Header
homeostasis/metabolism phenotype

IDG Resources

No IDG generated resources found

Orthologs (6)

1 – 5 of 6

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	bile acid-Coenzyme A: amino acid N-acyltransferase	MGI:106642	12012
Rat	bile acid CoA:amino acid N-acyltransferase	RGD:2190	29725
Dog	bile acid-CoA:amino acid N-acyltransferase		481635
Horse	bile acid-CoA:amino acid N-acyltransferase		100054567
Cow	acyl-coenzyme A amino acid N-acyltransferase 2		530653

Species	Name	OMA	EggNOG	Inparanoid
Mouse	bile acid-Coenzyme A: amino acid N-acyltransferase
Rat	bile acid CoA:amino acid N-acyltransferase
Dog	bile acid-CoA:amino acid N-acyltransferase
Horse	bile acid-CoA:amino acid N-acyltransferase
Cow	acyl-coenzyme A amino acid N-acyltransferase 2

Publication Statistics

PubMed Score 71.44

PubMed score by year

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PubTator Score 55.03

PubTator score by year

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Related Publications

Text Mined References (23)

GeneRif Annotations (11)

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PMID	Year	Title