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Tdark
EIF3CL
Eukaryotic translation initiation factor 3 subunit C-like protein

Protein Summary
Description
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. The protein encoded by this gene is a core subunit of the eukaryot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380876
  • ENSP00000370258
  • ENSG00000205609
  • ENST00000398944
  • ENSP00000381917
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.91
tissue
0.64
tissue sample
0.64
protein domain
0.58
protein complex
0.53


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.04   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 13   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.04   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 13   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
2
3
95.2
platelet count
2
2
2
94.4
platelet crit
2
2
3
91.9
intelligence
3
9
6
6.3
85.2
body mass index
6
2
8
83.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
95.2
platelet count
2
94.4
platelet crit
3
91.9
intelligence
6
6.3
85.2
body mass index
8
83.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 3 subunit C
454016
Mouse
MGI:1926966
56347
Rat
RGD:1308871
293484
Dog
eukaryotic translation initiation factor 3 subunit C
479795
Horse
eukaryotic translation initiation factor 3 subunit C
100064310
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 3 subunit C
Mouse
Rat
Dog
eukaryotic translation initiation factor 3 subunit C
Horse
eukaryotic translation initiation factor 3 subunit C
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-B5ME19-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (183)
1 – 10 of 183
EIF3I
Tbio
Novelty:  0.04398155
p_int:  0.999999997
p_ni:  3e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
EIF3E
Tbio
Novelty:  0.02154456
p_int:  0.999999995
p_ni:  5e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3H
Tbio
Novelty:  0.02564681
p_int:  0.999999993
p_ni:  7e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3M
Tbio
Novelty:  0.0174915
p_int:  0.999999992
p_ni:  8e-9
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3L
Tbio
Novelty:  0.11054104
p_int:  0.999999985
p_ni:  1.5e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3D
Tbio
Novelty:  0.0360717
p_int:  0.999999983
p_ni:  1.7e-8
Score:  0.995
Data Source:  BioPlex,STRINGDB
EIF3F
Tbio
Novelty:  0.0319772
p_int:  0.999999957
p_ni:  4.3e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3A
Tbio
Novelty:  0.00434615
Score:  0.999
Data Source:  STRINGDB
EIF3B
Tbio
Novelty:  0.00889042
Score:  0.998
Data Source:  STRINGDB
EIF3K
Tbio
Novelty:  0.04938688
Score:  0.998
Data Source:  STRINGDB
Publication Statistics
PubMed Score  6.04

PubMed score by year
PubTator Score  0.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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