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Tbio
B4GALT7
Beta-1,4-galactosyltransferase 7

Protein Summary
Description
Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts. This gene is a member of the beta-1,4-galactosyltransferase (beta4GalT) family. Family members encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose. Each beta4GalT member has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus which then remains uncleaved to function as a transmembrane anchor. The enzyme encoded by this gene attaches the first galactose in the common carbohydrate-protein linkage (GlcA-beta1,3-Gal-beta1,3-Gal-beta1,4-Xyl-beta1-O-Ser) found in proteoglycans. This enzyme differs from other beta4GalTs because it lacks the conserved Cys residues found in beta4GalT1-beta4GalT6 and it is located ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000029410
  • ENSP00000029410
  • ENSG00000027847

Symbol
  • XGALT1
  • XGPT
  • EDSP1
  • XGPT1
  • EDSSLA
  • XGALT1
  • EDSSPD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.72
cellular component
0.7
cell type or tissue
0.69
pathway
0.69
histone modification site profile
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.04   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.04   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (124)
GAA
Tclin
Family:  Enzyme
Novelty:  0.0063246
p_int:  0.984664989
p_ni:  0.01533501
p_wrong:  1e-9
Score:  0.211
Data Source:  BioPlex,STRINGDB
ADGRE5
Tbio
Family:  GPCR
Novelty:  0.01137558
p_int:  0.982284664
p_ni:  0.017715019
p_wrong:  3.18e-7
Data Source:  BioPlex
BTNL3
Tdark
Novelty:  0.27343899
p_int:  0.975571805
p_ni:  0.024421227
p_wrong:  0.000006968
Data Source:  BioPlex
GINM1
Tdark
Novelty:  1.0701107
p_int:  0.970140726
p_ni:  0.029859274
Data Source:  BioPlex
B4GAT1
Tbio
Family:  Enzyme
Novelty:  0.14959923
p_int:  0.968734177
p_ni:  0.031265821
p_wrong:  2e-9
Score:  0.318
Data Source:  BioPlex,STRINGDB
CRP
Tbio
Novelty:  0.00001517
p_int:  0.957762095
p_ni:  0.042237905
Data Source:  BioPlex
PTCH1
Tbio
Novelty:  0.00077635
p_int:  0.954470502
p_ni:  0.045527015
p_wrong:  0.000002483
Score:  0.178
Data Source:  BioPlex,STRINGDB
TSPAN31
Tbio
Novelty:  0.13580467
p_int:  0.881169524
p_ni:  0.118778539
p_wrong:  0.000051937
Data Source:  BioPlex
TMEM106A
Tbio
Novelty:  0.32470607
p_int:  0.869479563
p_ni:  0.130468806
p_wrong:  0.000051631
Data Source:  BioPlex
MPPE1
Tbio
Family:  Enzyme
Novelty:  0.16027847
p_int:  0.857139532
p_ni:  0.142807096
p_wrong:  0.000053372
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
A tetrasaccharide linker sequence is required for GAG synthesis
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Defective B4GALT7 causes EDS, progeroid type
Reactome
Disease
Reactome
Diseases associated with glycosaminoglycan metabolism
Name
Explore in Pharos
Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis
Chondroitin sulfate/dermatan sulfate metabolism
Defective B4GALT7 causes EDS, progeroid type
Disease
Diseases associated with glycosaminoglycan metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
49.5
heel bone mineral density
1
1
1
40.7
mathematical ability
1
1
1
6.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
49.5
heel bone mineral density
1
40.7
mathematical ability
1
6.5
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
beta-1,4-galactosyltransferase 7
VGNC:50754
664711
Macaque
beta-1,4-galactosyltransferase 7
701000
Mouse
MGI:2384987
218271
Rat
RGD:1309214
364675
Dog
beta-1,4-galactosyltransferase 7 [Source:HGNC Symbol;Acc:HGNC:930]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
beta-1,4-galactosyltransferase 7
Macaque
beta-1,4-galactosyltransferase 7
Mouse
Rat
Dog
beta-1,4-galactosyltransferase 7 [Source:HGNC Symbol;Acc:HGNC:930]
Publication Statistics
PubMed Score 49.04
PubMed score by year
PubTator Score 37.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title