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Tbio
B4GALT6
Beta-1,4-galactosyltransferase 6

Protein Summary
Description
Required for the biosynthesis of glycosphingolipids. This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene is a lactosylceramide synthase important for glycolipid biosynthesis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306851
  • ENSP00000306459
  • ENSG00000118276
  • ENST00000383131
  • ENSP00000372613

Symbol
  • B4Gal-T6
  • beta4Gal-T6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
co-expressed gene
0.85
kinase perturbation
0.84
PubMedID
0.8
histone modification site profile
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.69   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.69   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
EDDM3A
Tdark
Novelty:  0.05607223
p_int:  0.997672494
p_ni:  0.002301584
p_wrong:  0.000025922
Data Source:  BioPlex
LCN6
Tbio
Novelty:  0.11406686
p_int:  0.979057357
p_ni:  0.008197147
p_wrong:  0.012745496
Data Source:  BioPlex
FAM19A4
Tbio
Novelty:  0.04305684
p_int:  0.966671467
p_ni:  0.001154829
p_wrong:  0.032173704
Data Source:  BioPlex
SCGB2A1
Tbio
Novelty:  0.01902973
p_int:  0.964869148
p_ni:  0.0170119
p_wrong:  0.018118952
Data Source:  BioPlex
RTP1
Tbio
Novelty:  0.0278378
p_int:  0.963270334
p_ni:  0.013361654
p_wrong:  0.023368012
Data Source:  BioPlex
EPO
Tbio
Novelty:  0.00013701
p_int:  0.963169914
p_ni:  0.013917319
p_wrong:  0.022912767
Data Source:  BioPlex
MGAT4C
Tdark
Family:  Enzyme
Novelty:  0.19680806
p_int:  0.95445452
p_ni:  0.001404872
p_wrong:  0.044140608
Score:  0.691
Data Source:  BioPlex,STRINGDB
AVP
Tbio
Novelty:  0.00016475
p_int:  0.947821673
p_ni:  0.00101924
p_wrong:  0.051159087
Score:  0.188
Data Source:  BioPlex,STRINGDB
CST8
Tbio
Novelty:  0.02316886
p_int:  0.943718994
p_ni:  0.043470015
p_wrong:  0.012810991
Data Source:  BioPlex
MAN2A2
Tbio
Family:  Enzyme
Novelty:  0.07098345
p_int:  0.893714315
p_ni:  0.106285532
p_wrong:  1.53e-7
Score:  0.811
Data Source:  BioPlex,STRINGDB
Pathways (18)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Glycosaminoglycan metabolism
Reactome
Keratan sulfate biosynthesis
Reactome
Keratan sulfate/keratin metabolism
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Glycosaminoglycan metabolism
Keratan sulfate biosynthesis
Keratan sulfate/keratin metabolism
Metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thyroxine measurement
1
1
1
35
vitamin A measurement
1
1
1
13.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thyroxine measurement
1
35
vitamin A measurement
1
13.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
beta-1,4-galactosyltransferase 6
VGNC:8868
468512
Macaque
beta-1,4-galactosyltransferase 6
706068
Mouse
MGI:1928380
56386
Rat
RGD:71046
65196
Dog
beta-1,4-galactosyltransferase 6
VGNC:38354
490499
Species
Name
OMA
EggNOG
Inparanoid
Chimp
beta-1,4-galactosyltransferase 6
Macaque
beta-1,4-galactosyltransferase 6
Mouse
Rat
Dog
beta-1,4-galactosyltransferase 6
Publication Statistics
PubMed Score 10.69
PubMed score by year
PubTator Score 4.41
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title