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Tbio
B4GALT5
Beta-1,4-galactosyltransferase 5

Protein Summary
Description
Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The function of the enzyme encoded by this gene is not clear. This gene was previo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371711
  • ENSP00000360776
  • ENSG00000158470

Symbol
  • gt-V
  • B4Gal-T5
  • beta4Gal-T5
  • beta4GalT-V
  • BETA4-GALT-IV
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
kinase perturbation
0.88
transcription factor perturbation
0.84
transcription factor binding site profile
0.75
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.69   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.69   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
IL27RA
Tbio
Novelty:  0.01348051
p_int:  0.995107622
p_ni:  0.003942999
p_wrong:  0.000949379
Data Source:  BioPlex
HLA-DPA1
Tbio
Novelty:  0.01080446
p_int:  0.992226374
p_ni:  0.007773626
Data Source:  BioPlex
EPO
Tbio
Novelty:  0.00013701
p_int:  0.99149806
p_ni:  0.008490928
p_wrong:  0.000011012
Data Source:  BioPlex
C16orf92
Tdark
Novelty:  3.33740474
p_int:  0.988396981
p_ni:  0.01160221
p_wrong:  8.09e-7
Data Source:  BioPlex
IL20RB
Tbio
Novelty:  0.01747619
p_int:  0.985834138
p_ni:  0.014165862
Score:  0.169
Data Source:  BioPlex,STRINGDB
FCGRT
Tclin
Novelty:  0.00105713
p_int:  0.982852148
p_ni:  0.017147852
Data Source:  BioPlex
SLC39A9
Tbio
Family:  Transporter
Novelty:  0.06143625
p_int:  0.96908157
p_ni:  0.030751179
p_wrong:  0.000167251
Data Source:  BioPlex
FAM234B
Tdark
Novelty:  1.53957047
p_int:  0.953112825
p_ni:  0.043901434
p_wrong:  0.002985742
Data Source:  BioPlex
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.953025615
p_ni:  0.043717295
p_wrong:  0.003257091
Data Source:  BioPlex
SYT12
Tbio
Novelty:  0.03410873
p_int:  0.948317373
p_ni:  0.049850248
p_wrong:  0.001832379
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Glycosaminoglycan metabolism
Reactome
Keratan sulfate biosynthesis
Reactome
Keratan sulfate/keratin metabolism
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Glycosaminoglycan metabolism
Keratan sulfate biosynthesis
Keratan sulfate/keratin metabolism
Metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
0.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
0.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
beta-1,4-galactosyltransferase 5
VGNC:9823
458324
Macaque
beta-1,4-galactosyltransferase 5
713891
Mouse
MGI:1927169
56336
Dog
beta-1,4-galactosyltransferase 5
VGNC:38353
485920
Horse
beta-1,4-galactosyltransferase 5
VGNC:15743
100071419
Species
Name
OMA
EggNOG
Inparanoid
Chimp
beta-1,4-galactosyltransferase 5
Macaque
beta-1,4-galactosyltransferase 5
Mouse
Dog
beta-1,4-galactosyltransferase 5
Horse
beta-1,4-galactosyltransferase 5
Publication Statistics
PubMed Score 25.69
PubMed score by year
PubTator Score 35.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title