Tbio B4GALT5 Beta-1,4-galactosyltransferase 5

Protein Summary

Description

Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The function of the enzyme encoded by this gene is not clear. This gene was previously designated as B4GALT4 but was renamed to B4GALT5. In the literature it is also referred to as beta4GalT2. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O43286
• E1P625
• Q2M394
• Q9UJQ8
• Beta-1,4-GalTase 5

Gene Name

• B4GALT5

Ensembl ID

• ENST00000371711
• ENSP00000360776
• ENSG00000158470

Symbol

• gt-V
• B4Gal-T5
• beta4Gal-T5
• beta4GalT-V
• BETA4-GALT-IV

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
kinase perturbation	0.88
transcription factor perturbation	0.84
transcription factor binding site profile	0.75
disease perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Beta-1,4-galactosyltransferase 5

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / Beta-1,4-galactosyltransferase 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.29   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 153   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.29   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0