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Tbio
B4GALNT1
Beta-1,4 N-acetylgalactosaminyltransferase 1

Protein Summary
Description
Involved in the biosynthesis of gangliosides GM2, GD2 and GA2. GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids. GalNAc-T is the enzyme involved in the biosynthesis of G(M2) and G(D2) glycosphingolipids. GalNAc-T catalyzes the transfer of GalNAc into G(M3) and G(D3) by a beta-1,4 linkage, resulting in the synthesis of G(M2) and G(D2), respectively. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341156
  • ENSP00000341562
  • ENSG00000135454
  • ENST00000418555
  • ENSP00000401601
  • ENST00000550764
  • ENSP00000450303
  • ENST00000552350
  • ENSP00000448500

Symbol
  • GALGT
  • SIAT2
  • GALGT
  • SPG26
  • GALNACT
  • GalNAc-T
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.82
kinase perturbation
0.71
cellular component
0.68
disease perturbation
0.68
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.48   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 209   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.48   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0